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Deirdre Mac Loughlin , Galway Chamber Policy Strategy Committee , National Research Ethics Committee , Galway Chamber , Hp International , Mac Loughlin , Data Analytics ,

Acute rehabilitation following traumatic anterior shoulder dislocation (ARTISAN): pragmatic, multicentre, randomised controlled trial

Objective To assess the effects of an additional programme of physiotherapy in adults with a first-time traumatic shoulder dislocation compared with single session of advice, supporting materials, and option to self-refer to physiotherapy.

Design Pragmatic, multicentre, randomised controlled trial (ARTISAN).

Setting and participants Trauma research teams at 41 UK NHS Trust sites screened adults with a first time traumatic anterior shoulder dislocation confirmed radiologically, being managed non-operatively. People were excluded if they presented with both shoulders dislocated, had a neurovascular complication, or were considered for surgical management.

Interventions One session of advice, supporting materials, and option to self-refer to physiotherapy (n=240) was assessed against the same advice and supporting materials and an additional programme of physiotherapy (n=242). Analyses were on an intention-to-treat basis with secondary per protocol analyses.

Ma ....

East Suffolk , United Kingdom , North Yorkshire , West Suffolk , United Kingdom General , Glasgow City , City Of , West Midlands , Henry Nwankwo , Christopher Ratcliffe , Hannah Riley , Nicola Parker , Maria Mestre , Rachel Chester , Alison Armstrong , Rebeccas Kearney , Hannah Craig , Aileen Nacorda , Kathryn Allison , Fiona Carleton , Chandramohan Panneerselvam , Leanne Dymott , David Torgerson , David Bailey , Hayley Potter , Sarah Melling ,

Efficacy and safety of an inactivated virus-particle vaccine for SARS-CoV-2, BIV1-CovIran: randomised, placebo controlled, double blind, multicentre, phase 3 clinical trial

Objective To report the efficacy, safety, and exploratory immunogenicity findings of two 5 µg doses of the BIV1-CovIran vaccine.

Design Randomised, placebo controlled, double blind, multicentre, phase 3 clinical trial.

Setting In six cities of Iran, including Bushehr, Isfahan, Karaj, Mashhad, Shiraz, and Tehran. The first vaccine or placebo injection of the first participant was on 16 May 2021 in Tehran. The last vaccine or placebo injection of the last participant occurred on 15 July 2021 in Isfahan.

Participants 20 000 participants aged 18-75 years were randomly assigned to the intervention or placebo groups with a ratio of 2:1.

Intervention 5 µg vaccine or placebo with the interval of 28 days.

Main outcome measures Vaccine efficacy for a 90 day follow-up period, safety and explanatory immunogenicity assessment, and variant detection during the trial.

Results 20 000 participants were recruited and randomly assigned to receive BIV1-CovIr ....

Eteläuomen Läi , Asghar Abdoli , Farzin Khorvash , Shifa Pharmed , Mohammad Reza Malekpour , Hamed Hosseini , Minoo Mohraz , Sahar Saeedi Moghaddam , Maryam Amini Pouya , Katayoun Vahdat , Mohsen Abbasi Kangevari , Mohammadreza Salehi , Mohsen Moghadami , Rozita Khodashahi , Nazila Rezaei , Payam Tabarsi , Erfan Ghasemi , Hassan Jalili , Mohammad Taqavian , Keyvan Koohgir , Akbar Borandegi , Yasaman Ghabdian , Hamidreza Jamshidi , Iranian Research Centre , Amirabad Virology Laboratory , Shifa Pharmed Industrial Group ,