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Efficacy and safety of an inactivated virus-particle vaccine for SARS-CoV-2, BIV1-CovIran: randomised, placebo controlled, double blind, multicentre, phase 3 clinical trial

Objective To report the efficacy, safety, and exploratory immunogenicity findings of two 5 µg doses of the BIV1-CovIran vaccine.

Design Randomised, placebo controlled, double blind, multicentre, phase 3 clinical trial.

Setting In six cities of Iran, including Bushehr, Isfahan, Karaj, Mashhad, Shiraz, and Tehran. The first vaccine or placebo injection of the first participant was on 16 May 2021 in Tehran. The last vaccine or placebo injection of the last participant occurred on 15 July 2021 in Isfahan.

Participants 20 000 participants aged 18-75 years were randomly assigned to the intervention or placebo groups with a ratio of 2:1.

Intervention 5 µg vaccine or placebo with the interval of 28 days.

Main outcome measures Vaccine efficacy for a 90 day follow-up period, safety and explanatory immunogenicity assessment, and variant detection during the trial.

Results 20 000 participants were recruited and randomly assigned to receive BIV1-CovIr ....

Eteläuomen Läi , Asghar Abdoli , Farzin Khorvash , Shifa Pharmed , Mohammad Reza Malekpour , Hamed Hosseini , Minoo Mohraz , Sahar Saeedi Moghaddam , Maryam Amini Pouya , Katayoun Vahdat , Mohsen Abbasi Kangevari , Mohammadreza Salehi , Mohsen Moghadami , Rozita Khodashahi , Nazila Rezaei , Payam Tabarsi , Erfan Ghasemi , Hassan Jalili , Mohammad Taqavian , Keyvan Koohgir , Akbar Borandegi , Yasaman Ghabdian , Hamidreza Jamshidi , Iranian Research Centre , Amirabad Virology Laboratory , Shifa Pharmed Industrial Group ,

A year after reporting zero COVID deaths, Iran grapples with new wave

Iran was among first countries in Middle East to report coronavirus cases in February 2020 - Anadolu Agency ....

Turkey General , Mojtaba Neku , Coviran Baraket , Hossein Farshidi , Bahram Einollahi , Shariyar Haideri , Payam Tabarsi , Iran Health , Anadolu Agency , Health Ministry , Barakat Pharmaceutical Group , Health Minister Bahram Einollahi , Middle East , Pedram Pakaein , Iranian New Year , New Year , Health Minister Einollahi , Barakat Pharmaceutical , Masih Daneshvari Hospital , Broadcasting System , Covid 19 ,

Iran: New Wave of Coronavirus Outbreak Across the Country

Hospitalization rises 350%, 400%, 100%, and 97% in Gilan, South Khorasan, Khuzestan, and Khorasan Razavi provinces, respectively Ministry of Health: ....

Khorasane Janubi , Payam Tabresi , Minoo Mohraz , Payam Tabarsi , Khorasan Razavi , Alireza Zali , Quds Force News Agency , Television News Agency , Mashhad Medical Council Organization , Ministry Of Health , Birjand Medical University , Ahvaz Medical University , Mashhad Medical University , News Agency , Gilan Medical University , South Khorasan , Coronavirus Control Operations , Medical University , Khabar Online , Jaame Jam ,

Iranian press review: Iranian women call for ban on motorcycle licences to be overturned

Meanwhile, Iran hits a new coronavirus daily case record, fat-cat bonuses for state bank managers spark anger, and Raisi must tackle economic woes ....

Iran General , Meysam Hashemkhani , Saeed Namaki , Payam Tabarsi , Kamran Naderi , Tejarat Bank , Masih Daneshvari Hospital , President Elect Ebrahim Raisi ,

Iran: Coronavirus Death Toll Exceeds 498,500

On Monday, January 10, 2022, the Coronavirus death toll in 547 Iranian cities surpassed 496,600. ....

Payam Tabarsi , Khorasan Razavi , Hormozgan Medical University , People Mojahedin Organization Of Iran , Health Ministry , Scientific Committee , National Coronavirus Combat Taskforce , Masih Daneshvari Hospital , Medical University , Mojahedin Organization , South Khorasan ,