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New study charts the complexity of SARS-CoV-2 neutralization

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Washington, DC - February 24, 2021 - In the absence of effective treatments for COVID-19, many countries have approved the therapeutic use of blood plasma from recovering patients because it contains antibodies against the coronavirus. But not every type of antibody can neutralize the virus and render it noninfectious. New research published this week in
mSphere, an open-access journal of the American Society for Microbiology, explores variation in virus neutralization capabilities, which can vary widely by type of antibody.
What we need for plasma therapy is not only high levels of antibodies but also high neutralization capability, said virologist Michael Schindler, Ph.D, at University Hospital Tübingen, in Germany. ....

South Africa , United States , Michael Schindler , Natalia Ruetalo , American Society For Microbiology , University Hospital , American Society , ஒன்றுபட்டது மாநிலங்களில் , மைக்கேல் ஶிஂட்லர் , அமெரிக்கன் சமூகம் க்கு நுண்ணுயிரியல் , பல்கலைக்கழகம் மருத்துவமனை , அமெரிக்கன் சமூகம் ,

New promising antibodies against SARS-CoV-2

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IMAGE: Cell culture plates with stained cells, in which virus replication can be quantified by the ‚holes that virus infection causes in the cell lawn.
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Credit: © Volker Lannert/ University of Bonn
Antibodies are an important weapon in the immune system s defense against infections. They bind to the surface structures of bacteria or viruses and prevent their replication. One strategy in the fight against disease is therefore to produce effective antibodies in large quantities and inject them into the patients. The outgoing US President Donald Trump probably owes his rapid recovery to this method. However, the antibodies used to treat him have a complex structure, do not penetrate very deeply into the tissue and may cause unwanted complications. Moreover, producing antibodies is difficult and time-consuming. They are therefore probably not suitable for widespread use. ....

United States , Nordrhein Westfalen , Lea Marie Jenster , Matthias Geyer , Yonasm Tesfamariam , Donald Trump , Jenniferd Wuerth , Floriann Gohr , Jonathan Leo Schmid Burgk , Lisadj Schiffelers , Kerstinu Ludwig , Sabine Normann , Carolinei Fandrey , Michael Schindler , Hiroki Kato , Provendis Gmb , Emmy Noether , Hejun Liu , Mariah Christensen , Hrishikesh Das , Natalia Ruetalo , Karolinska Institutet , Tiana Wilson , Leo Hanke , Nicholas Wu , Floriani Schmidt ,

New small antibodies show promising effects against COVID-19 infection

Researchers have stitched together nanobodies (green and red) that bind to two different places on the spike protein of SARS-CoV-2. Image by Hrishikesh. ....

United States , Nordrhein Westfalen , Lea Marie Jenster , Matthias Geyer , Yonasm Tesfamariam , Jenniferd Wuerth , Floriann Gohr , Jonathan Leo Schmid Burgk , Lisadj Schiffelers , Kerstinu Ludwig , Ulf Sirborn Martin , Sabine Normann , Carolinei Fandrey , Michael Schindler , Hiroki Kato , Hejun Liu , Mariah Christensen , Hrishikesh Das , Natalia Ruetalo , Karolinska Institutet , Tiana Wilson , Leo Hanke , Floriani Schmidt , Steffen Pritzl , Karl Gatterdam , Nicholasc Wu ,