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Treating mice with so-called 'nanobodies'

New promising antibodies against SARS-CoV-2

 E-Mail IMAGE: Cell culture plates with stained cells, in which virus replication can be quantified by the ‚holes that virus infection causes in the cell lawn. view more  Credit: © Volker Lannert/ University of Bonn Antibodies are an important weapon in the immune system s defense against infections. They bind to the surface structures of bacteria or viruses and prevent their replication. One strategy in the fight against disease is therefore to produce effective antibodies in large quantities and inject them into the patients. The outgoing US President Donald Trump probably owes his rapid recovery to this method. However, the antibodies used to treat him have a complex structure, do not penetrate very deeply into the tissue and may cause unwanted complications. Moreover, producing antibodies is difficult and time-consuming. They are therefore probably not suitable for widespread use.

New small antibodies show promising effects against COVID-19 infection

Researchers have stitched together nanobodies (green and red) that bind to two different places on the spike protein of SARS-CoV-2. Image by Hrishikesh.