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Vaccine boosts innate immunity in people with

<p><strong>Bacillus Calmette-Gu&eacute;rin (BCG) is one of the world&rsquo;s oldest and most widely used vaccines. It was developed in the early 20<sup>th</sup> century to provide protection from tuberculosis. Surprisingly, this vaccine protects not only against tuberculosis but also reduces the risk for various other infections, through a mechanism called trained immunity. A new study led by Christoph Bock and Mihai Netea found that epigenetic cell states predict whether or not an individual profits from the &ldquo;wake-up call&rdquo; to the innate immune system that is provided by the BCG vaccine. This discovery contributes to the development of future therapeutics that induce protective trained immunity.</strong></p>

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