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A dedicated hypothalamic oxytocin circuit controls aversive social learning

To survive in a complex social group, one needs to know who to approach and, more importantly, who to avoid. In mice, a single defeat causes the losing mouse to stay away from the winner for weeks1. Here through a series of functional manipulation and recording experiments, we identify oxytocin neurons in the retrochiasmatic supraoptic nucleus (SOROXT) and oxytocin-receptor-expressing cells in the anterior subdivision of the ventromedial hypothalamus, ventrolateral part (aVMHvlOXTR) as a key circuit motif for defeat-induced social avoidance. Before defeat, aVMHvlOXTR cells minimally respond to aggressor cues. During defeat, aVMHvlOXTR cells are highly activated and, with the help of an exclusive oxytocin supply from the SOR, potentiate their responses to aggressor cues. After defeat, strong aggressor-induced aVMHvlOXTR cell activation drives the animal to avoid the aggressor and minimizes future defeat. Our study uncovers a neural process that supports rapid social learning caused by d ....

Development Team , California Institute Of Technology , Brain Funct , Early Childhood Education , Brain Res , Cell Rep , Tissue Res , Multimodal Analysis , Cell Types , Hypothalamic Node Controlling Social Behavior , California Institute , Mouse Brain , Academic Press ,

Droplet microarrays for high throughput analysis of biochemical samples and single cells

Droplet microarrays for high throughput analysis of biochemical samples and single cells
wiley.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from wiley.com Daily Mail and Mail on Sunday newspapers.

Angewandte Chemie , Bioanalytics Group , Angewandte Chemie International Edition , A Lab , Copyright Bioanalytics Group , Advances In Microfluidic Technology For Bioanalysis , Recent Advances , Microfluidic Technology , Droplet Microfluidics , Directed Evolution , Angewandte Chemie International , Throughput Screening , Artificial Metalloenzyme , Droplet Barcoding , Single Cell Transcriptomics Applied , Embryonic Stem , Vis Spectra Activated Droplet Sorting , Label Free Chemical Identification , Continuous Electroformation , Gold Nanoparticles , Nanoliter Droplet , In Droplet Electrophoretic Separation , High Resolution Droplet Based Fractionation , Microfluidic Platform , Multimodal Analysis , Enzyme Secretion ,

NewCa.com: Canadian Heritage Funds Projects To Strengthen

- Projects funded through the Digital Citizen Contribution Program will strengthen citizens critical thinking about disinformation and counter online harms -
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United Kingdom , New Brunswick , Dominic Leblanc , Pablo Rodriguez , Heidi Tworek , Nanjala Nyabola , Taylor Owen , Students Commission Of Canada , Global Reporting Centre , Canadian Heritage Digital Citizen Initiative , Centre For The Study Of Democratic Institutions , Digital Citizen Contribution Program , Family Services Of Peel , Digital Citizen Initiative , University Of Waterloo , Services Association , University Of British Columbia , Mcgill University , Alliance Jeunesse Famille , Media Lab , Access Network , Audience Lab , Macewan University , Norquest College , Leadership Africain , Concordia University ,