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Good Results, But Small Numbers With JenaValve Trilogy in Severe AR

Treatments are limited for surgery-ineligible patients with severe AR, but this particular TAVI system is raising hopes. ....

United States , City Of , United Kingdom , Andrew Goldsweig , Firas Zahr , Science University , Jenavalve Technology , Md Oregon Health , Drug Administration , Ms University Of Nebraska Medical Center , Md University Hospital Cologne Heart Center , Technology Promising , Matti Adam , University Hospital Cologne Heart Center , Jenavalve Trilogy , European Society , European Association , Cardio Thoracic Surgery , Oregon Health , Nebraska Medical Center , Framingham Heart Study ,

Excluded from Pivotal Trials, Low-risk Complex Patients Warrant Caution

January 22, 2021
A significant proportion of real-world patients with severe aortic stenosis and low surgical risk have an additional valvular or CV condition that was never accounted for in pivotal trials of TAVI versus SAVR and that requires a serious discussion by the heart team, Canadian research shows.
In the study of primarily low-risk patients who underwent SAVR between 2000 and 2019, 40.8% had at least one of the following conditions: non-tricuspid aortic valve (NTAV), severe coronary artery disease (SevCAD), concomitant mitral/tricuspid valve (CMTV), or concomitant ascending aorta replacement (CAAR). All four of those patient subgroups were routinely excluded from RCTs of TAVI compared with SAVR. ....

New York , United States , Alberto Alperi , Gilbert Tang , Poonam Velagapudi , Md Mount Sinai Health System , Journal Of The American College Cardiology , Ms University Of Nebraska Medical Center , Md Laval University , Laval University , American College , Mount Sinai Health System , Holistic Approach , Nebraska Medical Center , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , கில்பர்ட் டாங் , பூனம் வேலகப்பூடி , ம்ட் ஏற்ற சினை ஆரோக்கியம் அமைப்பு , இதழ் ஆஃப் தி அமெரிக்கன் கல்லூரி இருதயவியல் , செல்வி பல்கலைக்கழகம் ஆஃப் நெப்ராஸ்கா மருத்துவ மையம் , ம்ட் லாவள் பல்கலைக்கழகம் , லாவள் பல்கலைக்கழகம் , அமெரிக்கன் கல்லூரி , ஏற்ற சினை ஆரோக்கியம் அமைப்பு , முழுமையான அணுகுமுறை ,