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Model of neuromuscular junction could accelerate new treatments for neuromuscular diseases

The neuromuscular junction-;where nerves and muscle fibers meet-;is an essential synapse for muscle contraction and movement. ....

New York , United States , San Francisco , Lou Gehrig , Gordana Vunjak Novakovic , David Rampulla , Emily Henderson , Division Of Discovery Science Technology , University Professor , Discovery Science , Mikati Foundation Professor , Biomedical Engineering , Columbia University , Lou Gehrig 39s Disease , Motor Neurons ,

Single-patient pilot study shows the ability of antisense oligonucleotide to suppress mutant ALS gene

Using a short, synthetic chain of chemically modified nucleotides engineered in the RNA Therapeutics Institute at UMass Chan Medical School, Robert H. Brown Jr., DPhil, MD, Jonathan Watts, PhD, and colleagues have shown the ability to suppress mutant forms of an ALS gene known as C9ORF72 in a single-patient pilot study. ....

United States , United Kingdom , Helene Tran , Theresam Lachance , Umass Chan , Jonathan Watts , Roberth Brown Jr , Emily Henderson , National Institutes Of Health , Drug Administration , Oxford University Medical School , Therapeutics Institute , Watts Lab , Angel Fund , Cellucci Fund , Research Fund , Umass Chan Medical School , Chan Medical School , Nature Medicine , Chance Chair , Medical Research , Chan Medical , Michael Moazami Phd , National Institutes , Max Rosenfeld , Clinical Trial ,

Study analyzes the role of circular RNA in ALS pathology

Amyotrophic lateral sclerosis, known as ALS, is a neurodegenerative disorder which affects motor neurons. These are the neuronal cells responsible for muscle innervation, whose degenerations leads to progressive paralysis culminating with motor and respiratory failure. ....

Irene Bozzoni , Mariangela Morlando , Emily Henderson , Centre For Life Nano Neuro , University Of Perugia , Science Of The Italian Institute Technology , Sapienza University , Charles Darwin Department , Italian Institute , Amyotrophic Lateral Sclerosis , Motor Neurons , Neurodegenerative Disorder ,

QurAlis Presents New Data Confirming Role of STATHMIN-2 in Neuronal Disease Biology at 32nd International Symposium on ALS/MND

Press release content from PR Newswire. The AP news staff was not involved in its creation. ....

United Kingdom , Jason Bussgang , Erika Norabuena , Yasmin Hamwi , James Chow , Kevin Eggan , Qurali Asos , Sandy Hinckley , Marisa Kamelgarn , Daniel Elbaum , Taylor Gray , Harvard University , International Symposium , Harvard Medical School , Eggan Lab , Quralis Corporation , Prnewswire Quralis Corporation , Alis Corporation , Time Course , Protein Abundance , Golgi Apparatus Morphology , Neurite Outgrowth , Proteotoxic Stress , Human Induced Pluripotent Derived Motor Neurons , Abstract Number , Qurali Chief Scientific Officer ,

Targeting the brain should be the focus of ALS therapy, not just spinal cord

The brain is indeed a target for treating ALS (amyotrophic lateral sclerosis), Northwestern Medicine scientists have discovered. ....

Hande Ozdinler , Emily Henderson , Northwestern University , Northwestern University Feinberg School Of Medicine , Northwestern Medicine , Northwestern University Feinberg School , Amyotrophic Lateral Sclerosis , Gene Therapy , Motor Neuron Disease , Motor Neuron Diseases , Motor Neurons ,