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"Entirely New" Perspective on ALS Offered by Astrocyte Finding

Research has discovered that an inorganic polyphosphate released by astrocytes in people with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) contributes to the motor neuron death that is the signature of these diseases. ....

United States , Theresam Lachance , Umass Chan , Brigitte Van Zundert , Roberth Brown Jr , Universidad Andres Bello , Chance Chair ,

Researchers identify motor neuron toxin associated with ALS

An international team of investigators has discovered that an inorganic polyphosphate released by nerve cells known as astrocytes in people with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) contributes to the motor neuron death that is the signature of these diseases. ....

Theresam Lachance , Umass Chan , Brigitte Van Zundert , Roberth Brown Jr , Emily Henderson , Universidad Andres Bello , Chance Chair , Amyotrophic Lateral Sclerosis , Frontotemporal Dementia , Medical Research , Motor Neurons ,

Motor Neuron Toxin Linked to Amyotrophic Lateral Sclerosis Identified

Previous research has shown that astrocytes may release one or more toxic factors that contribute to motor neuron death. Now, a new mouse study demonstrates how astrocytes release an inorganic polyphosphate (polyP) in people with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) that contributes to the motor neuron death. ....

Theresam Lachance , Umass Chan , Brigitte Van Zundert , Roberth Brown Jr , University Of Massachusetts Umass Chan Medical School , Chan Medical ,