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'No level of smoke exposure is safe'

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IMAGE: associate director for population science and interim co-leader of the Cancer Prevention and Control program at VCU Massey Cancer Center
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Credit: VCU Massey Cancer Center
Nearly a quarter of pregnant women say they ve been around secondhand smoke - in their homes, at work, around a friend or relative - which, according to new research, is linked to epigenetic changes - meaning changes to how genes are regulated rather than changes to the genetic code itself - in babies that could raise the risk of developmental disorders and cancer.
The study, published today in
Environmental Health Perspectives by researchers at Virginia Commonwealth University Massey Cancer Center, is the first to connect secondhand smoke during pregnancy with epigenetic modifications to disease-related genes, measured at birth, which supports the idea that many adult diseases have their origins in environmental exposures - such as stress, poor nutriti ....

Carole Grenier , Rachel Maguire , Cathrine Hoyo , Mikhail Dozmorov , Junfeng Jim Zhang , Bernard Fuemmeler , Scott Kollins , Gordond Ginder , Zhiqing Huang , Susan Murphy , Cancer Research At Massey , School Of Medicine , Environmental Protection Agency , National Cancer Institute , National Institutes Of Health , Environmental Health Perspectives , Virginia Commonwealth University Massey Cancer Center , Duke Comprehensive Cancer Center , Carolina State University , Duke University , Massey Cancer Center , Cancer Prevention , Newborn Epigenetics Study , Cancer Research , Cancer Biology , North Carolina State ,

Abundance of iron drives cell death and could inform novel treatments for neuroblastoma

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IMAGE: This image shows expression of a specific ferroptosis marker called TfR1 in MYCN-amplified neuroblastoma tissues before and after treatment with auranofin, an FDA-approved drug for rheumatoid arthritis.
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Credit: VCU Massey Cancer Center
Neuroblastoma is a cancer that develops in nerve tissue, most commonly in the glands around the kidneys. The gene MYCN is overexpressed in 20-25% of neuroblastoma, and MYCN-amplified neuroblastoma contributes to a considerable percentage of pediatric cancer-related deaths.
Anthony Faber, Ph.D., and a team of researchers at VCU Massey Cancer Center were awarded a grant from the American Cancer Society to study how MYCN and an abundance of iron can drive cancer cell death in neuroblastoma and potentially be targeted with novel treatments. This award is the first part of a potential two-stage grant worth a combined total of $600,000. ....

United States , Janina Lewis , Krista Powell , Sosipatros Boikos , Mayuri Shende , Sivapriya Ramamoorthy , Mikhail Dozmorov , Colin Coon , Richard Kurupi , Anthony Faber , Konstantinos Floros , Madhavi Puchalapalli , Johnr Congdon , Carter Fairchild , Jennifer Koblinski , School Of Medicine , Metabolon Inc , School Of Dentistry , Cancer Research , Mission Boost Grant , Phillips Institute For Oral Health Research , Philips Institute For Oral Health Research , Department Of Pathology , Massey Cancer Center , Pediatric Oncology Branch , American Cancer Society ,

Immune cell that drives breast cancer could be effective target in novel immunotherapies

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IMAGE: New research findings from Paula Bos, Ph.D., identified a type of immune cells that acts as a major driver of breast cancer growth by preventing the accumulation of a specific.
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Credit: VCU Massey Cancer Center
Breast cancer is the most common cancer in women worldwide, but many immunotherapies have had limited success in treating aggressive forms of the disease.
A deeper understanding of the immunobiology of breast cancer is critical to the success in harnessing immunotherapeutic approaches to improve breast cancer survival, said Paula Bos, Ph.D., member of the Cancer Biology research program at VCU Massey Cancer Center and assistant professor in the Department of Pathology at the VCU School of Medicine. ....

Leandro Martinez , Steven Murdock , Amy Olex , Paula Bos , Mikhail Dozmorov , Nicholas Clark , School Of Medicine , Department Of Pathology , Dianne Wright Center , Massey Cancer Center , Translational Research , Cancer Biology , Cancer Center , Cell Reports , Comfort Effi , லியாண்ட்ரோ மார்டினெஸ் , ஸ்டீவன் மர்டாக் , ஆமி ஒலெக்ஷ , பால போஸ் , நிக்கோலஸ் கிளார்க் , பள்ளி ஆஃப் மருந்து , துறை ஆஃப் நோயியல் , டயான் ரைட் மையம் , மஸ்ஸி புற்றுநோய் மையம் , மொழிபெயர்ப்பு ஆராய்ச்சி , புற்றுநோய் உயிரியல் ,