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Mitochondria of diabetic patients can't keep track of time

Circadian rhythm in skeletal muscle cells of type 2 diabetic patients vs healthy individuals. Illustration by Brendan Gabriel, produced with ....

Zhengye Liu , Zhiguang Huo , Ali Altintas , Astridl Basse , Jonast Treebak , Brendanm Gabriel , Elsa Goljes Minne , Anna Krook , Nicolasj Pillon , Brendan Gabriel , Hui Gao , Juleen Zierath , Jonathonab Smith , Juleenr Zierath , Karolinska Institutet , Karyna Esser , Antonio Zorzano , Laura Sardon Puig , Romain Barr , Lucile Dollet , Ulf Sirborn , Xiping Zhang , Stockholm County Council , University Of Copenhagen , Alice Wallenberg Foundation , European Foundation For The Study Of Diabetes ,

Microarchitecture and Insulin Responsiveness of Fat Cells Uncovered by Spatial Transcriptomics

Fat cells affect the body’s sensitivity to insulin. Applying an spatial transcriptomics approach, researchers at Karolinska Institute, Sweden, have discovered that there are 18 types of fat cells in white fat tissue including three different subtypes of mature fat cells only one of which responds to insulin. The findings may be relevant for future treatments of metabolic diseases such as insulin-resistant type 2 diabetes and obesity. ....

Niklas Mejhert , Karolinska Institute , Department Of Medicine , Mikael Ryd , துறை ஆஃப் மருந்து , மைக்கேல் றய்த் ,

Only one human fat cell subtype responds to insulin stimulation

Only one human fat cell subtype responds to insulin stimulation
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Alma Andersson , Karolinska Institutet , Niklas Mejhert , Astra Zeneca , Jutta Jalkanen , Knut Alice Wallenberg , Ulf Sirborn , Anders Thorell , Qian Li , Nayanika Bhalla , Hui Gao , Nancy Farese , Lovisa Franz , Swedish Research Council , Erling Persson Family Foundation , Royal Institute Of Technology , Novonordisk Foundation , Department Of Medicine , Swedish Diabetes Foundation , Cell Metabolism , Mikael Ryd , Alice Wallenberg , Region Stockholm , Strategic Research Program , Mapping Reveals Human Adipocyte Subpopulations , Distinct Sensitivities ,