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Rare bacterial strain yields groundbreaking compounds to combat hepatitis B

Scientists have discovered new antiviral compounds from a rare bacterial strain, offering a novel approach to target hepatitis B virus. These compounds work by altering membrane permeability in infected cells, leading to the release of immature viral particles, a mechanism distinct from current HBV treatments. ....

Sanchari Sinha Dutta , Institute Of Microbial Chemistry , Microbial Chemistry , Hepatitis B , Hepatitisb Virus , Hepatocellular Carcinoma ,

Study Suggests Mechanistic Link between Gastric Cancer and H. pylori Infection

Study Suggests Mechanistic Link between Gastric Cancer and H. pylori Infection
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Atsushi Takahashi Kanemitsu , Masanori Hatakeyama , Institute Of Microbial Chemistry , Juntendo University , Laboratory Head , Microbial Chemistry Research Foundation , Science Signaling , Van Gogh Like , Microbial Chemistry ,

New study throws light on mechanisms underlyi

Helicobacter pylori cagA+ strains cause gastric inflammation, ulcers, and cancer. Previous reports have shown that the cagA gene-encoded protein “CagA” plays a crucial role in gastric carcinogenesis. However, the underlying mechanisms remain to be fully elucidated. Researchers from Japan used animal models and laboratory-cultured human gastric epithelial cells to demonstrate that CagA works by disrupting the Wnt/Planar Cell Polarity (PCP) signaling pathway. ....

National University Of Singapore , Singapore General , Mengxue Lu , Christopher Takaya Knight , Takayoshi Yamamoto , Ippei Kikuchi , Atsushi Takahashi Kanemitsu , Etsuoa Susaki , Akira Kikuchi , Takuya Ooki , Nick Barker , Masanori Taira , Christophert Knight , Yusuke Mii , Masanori Hatakeyama , Takuo Hayashi , Department Of Molecular Biology , Akira Kikuchi Osaka University , Department Of Biological Sciences , Research Center , Takuo Hayashi Juntendo University , Ippei Kikuchi Institute Of Microbial Chemistry , Yong Loo Lin School Of Medicine , Laboratory Head , National Institute For Basic Biology , Laboratory Of Microbial Carcinogenesis ,