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Single-cell genome sequencing provides a new way to think about Alzheimer's disease

Alzheimer's disease is marked by a loss of functional neurons in the brain. But what causes this loss? Through single-cell genome sequencing, researchers at Boston Children's Hospital, Brigham and Women's Hospital, and the Broad Institute show that people with Alzheimer's have an abundance of newly acquired mutations in their neurons -; more than people of the same age without Alzheimer's, and enough to disable genes important to brain function. ....

United States , August Yue Huang , Michaelb Miller , Christopher Walsh , Alice Lee , Emily Henderson , Broad Institute , Boston Children , Howard Hughes Medical Institutes , Lzheimer 39s Disease , Dna Damage , Medical School , Neurodegenerative Diseases ,

In Alzheimer's, DNA errors stress cells, create dysfunction – Harvard Gazette

A new study by Harvard-affiliated researchers finds that patients with Alzheimer’s disease have both more and different somatic mutations alterations in DNA in their brain cells than people without Alzheimer’s disease. ....

United States , Michaelb Miller , Christophera Walsh , Department Of Pathology , Boston Children , Third Rock Ventures , Flagship Pioneering , Clinical Advisory Board , Alzheimer 039s Disease , Somatic Mutations ,