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Older heart muscle cells accumulate new genetic mutations -; while losing the ability to repair them

Why does the risk of heart disease go up as we age? Known risk factors such as hypertension or high cholesterol don't explain all cases. ....

United States , Ming Hui Chen , August Yue Huang , Sangita Choudhury , Eunjung Alice Lee , Christopher Walsh , Emily Henderson , Division Of Genetics , Department Of Cardiology At Boston Children , Boston Children , Dna Damage , Heart Disease , High Cholesterol ,

Somatic Mutations Accrue in Alzheimer's Neurons

Somatic Mutations Accrue in Alzheimer's Neurons
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New York , United States , Carles Boix , Karl Herrup , Huntington Potter , Michael Miller , Eunjung Alice Lee , Manolis Kellis , Jerold Chun , Mark Mattson , Rxiv Kousi , August Yue Huang , Chunyu Liu , Maria Kousi , Ekaterina Rogaeva , Christopher Walsh , Chelsea Weidman Burke , Johns Hopkins University , University Of Toronto , University Of Colorado , University Of Pittsburgh Medical Center , Massachusetts Alzheimer Disease Research Center , Michael Lodato , Boston Children , Pittsburgh Medical Center , Massachusetts Alzheimer ,

Single-cell DNA sequencing offers new angle on causes of Alzheimer's

Single-cell DNA sequencing offers new angle on causes of Alzheimer's
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United States , University Of Massachusetts , August Yue Huang , Michaelb Miller , Eunjung Alice Lee , Michael Lodato , Christopher Walsh , Alice Lee , Broad Institute , National Institutes Of Health , Suh Kyungbae Foundation , Harvard Medical School , University Of Massachusetts Chan Medical School , Howard Hughes Medical Institute Investigator , National Academy Of Medicine , Women Hospital Program For Interdisciplinary Neuroscience , Paulg Allen Family Foundation , National Academy Of Sciences , Doris Duke Charitable Foundation , Allen Discovery Center , Brightfocus Foundation , Boston Children , Howard Hughes Medical Institutes , Massachusetts Chan Medical , National Institutes , Hospital Program ,

Single-Cell DNA Sequencing Offers a New Angle on the Causes of Alzheimer's Disease

An abundance of newly acquired mutations in the mutations that occur at an accelerated speed is a telling pattern of Alzheimer's disease, researchers report. ....

United States , University Of Massachusetts , Bethany Tripp , August Yue Huang , Michaelb Miller , Eunjung Alice Lee , Michael Lodato , Christopher Walsh , Alice Lee , Broad Institute , National Institutes Of Health , Suh Kyungbae Foundation , University Of Massachusetts Chan Medical School , Howard Hughes Medical Institute Investigator , Women Hospital Program For Interdisciplinary Neuroscience , Paulg Allen Family Foundation , Doris Duke Charitable Foundation , Allen Discovery Center , Brightfocus Foundation , Boston Children , Howard Hughes Medical Institutes , Massachusetts Chan Medical , National Institutes , Hospital Program , Interdisciplinary Neuroscience , Howard Hughes Medical Institute ,