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Teetotaler Bill Gates invests Sh118b in Heineken

Teetotaler Bill Gates invests Sh118b in Heineken
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United States , Bill Gates , Heineken Holding , Melinda Gates Investment , Melinda Gates Foundation , Netherland Financial Markets Authority , Melinda Gates Investment Trust ,

Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity


SUMMARY
Vaccination elicits immune responses capable of potently neutralizing SARS-CoV-2. However, ongoing surveillance has revealed the emergence of variants harboring mutations in spike, the main target of neutralizing antibodies. To understand the impact of these variants, we evaluated the neutralization potency of 99 individuals that received one or two doses of either BNT162b2 or mRNA-1273 vaccines against pseudoviruses representing 10 globally circulating strains of SARS-CoV-2. Five of the 10 pseudoviruses, harboring receptor-binding domain mutations, including K417N/T, E484K, and N501Y, were highly resistant to neutralization. Cross-neutralization of B.1.351 variants was comparable to SARS-CoV and bat-derived WIV1-CoV, suggesting that a relatively small number of mutations can mediate potent escape from vaccine responses. While the clinical impact of neutralization resistance remains uncertain, these results highlight the potential for variants to escape from neutralizi ....

Lambertus Family Foundation , Gilead Sciences Research Scholars Program , National Institutes For Drug Abuse , Massachusetts Consortium On Pathogenesis Readiness Mass , Charlesh Hood Foundation , Transformative Scholars Program , Department Of Science , National Institute , African Medical Research Council , General Medical , Melinda Gates Investment , South African Medical Research Council , Massachusetts Consortium , Pathogenesis Readiness , Lambertus Family , National Institutes , Drug Abuse , Avenir New Innovator Award , Scholars Program , Partners Institutional Review Board , கிலியட் அறிவியல் ஆராய்ச்சி அறிஞர்கள் ப்ரோக்ர்யாம் , தேசிய நிறுவனங்கள் க்கு மருந்து , உருமாறும் அறிஞர்கள் ப்ரோக்ர்யாம் , துறை ஆஃப் அறிவியல் , தேசிய நிறுவனம் , ஜநரல் மருத்துவ ,