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DarwinHealth Scientists Publish Foundational Research Identifying Regulatory Mechanisms Controlling Cancer Cell States and Drug Response

DarwinHealth Scientists Publish Foundational Research Identifying Regulatory Mechanisms Controlling Cancer Cell States and Drug Response
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NEW YORK, Jan. 11, 2021 /PRNewswire/ DarwinHealth, Inc., a New York-based biotechnology and cancer drug discovery company announces the January 11, 2021 online publication in
Cell of a landmark paper, A Modular Master Regulator Landscape Controls Cancer Transcriptional Identity,
1,2 in which scientists from Columbia University and DarwinHealth apply the VIPER (Virtual Inference of Protein activity by Enriched Regulon) analysis algorithm to identify recurrent regulatory networks tumor checkpoints operative across the pancancer subtype continuum.
This research paper, with lead author Dr. Evan Paull, from the Department of Systems Biology at Columbia University, in conjunction with DarwinHealth Co-Founder, Professor Andrea Califano and Chief Scientific Office ....

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DarwinHealth Scientists Publish Foundational Research Identifying [...] | Comunicati stampa CataniaOggi

12 gennaio 2021 07:40
Fonte: Adnkronos
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NEW YORK, Jan. 11, 2021 /PRNewswire/ DarwinHealth, Inc., a New York-based biotechnology and cancer drug discovery company announces the January 11, 2021 online publication in Cell of a landmark paper, A Modular Master Regulator Landscape Controls Cancer Transcriptional Identity, 1,2 in which scientists from Columbia University and DarwinHealth apply the VIPER (Virtual Inference of Protein activity by Enriched Regulon) analysis algorithm to identify recurrent regulatory networks tumor checkpoints operative across the pancancer subtype continuum.
This research paper, with lead author Dr. Evan Paull, from the Department of Systems Biology at Columbia University, in conjunction with DarwinHealth Co-Founder, Professor Andrea Califano and Chief Scientific Officer, Dr. Mariano Alvarez and other investigators, presents results and analyses, using a novel Multi-Omics Master-Regulator Analysis framework (MOMA) ....

New York , United States , Columbia University , Asuntos Economicosy Transformacion , Andrea Califano , Evan Paull , Mariano Alvarez , Salud Carlos , Darwinhealth Co , Department Of Systems Biology At Columbia University , Prnewswire Darwinhealth Inc , Us National Institutes Of Health , New York Based , Virtual Inference , Enriched Regulon , Systems Biology , Darwinhealth Co Founder , Professor Andrea Califano , Chief Scientific Officer , Multi Omics Master Regulator Analysis , Instituto De Salud Carlos , Ministerio De Asuntos Economicos , Transformacion Digital , Master Regulator , Master Regulators , Master Regulator Blocks ,

Big data analysis finds cancer's key vulnerabilities

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NEW YORK, NY (Jan. 11, 2021) Thousands of different genetic mutations have been implicated in cancer, but a new analysis of almost 10,000 patients found that regardless of the cancer s origin, tumors could be stratified in only 112 subtypes and that, within each subtype, the Master Regulator proteins that control the cancer s transcriptional state were virtually identical, independent of the specific genetic mutations of each patient.
The study, published Jan. 11 in
Cell, confirms that Master Regulators provide the molecular logic that integrates the effect of many different and patient-specific mutations to implement the transcriptional state of a specific tumor subtype, thus greatly expanding the fraction of patients who may respond to the same treatment. ....

New York , United States , Mailman School Of Public Health , Columbia University , Lhospitalet De Llobregat , Comunidad Autonoma De Cataluna , Asuntos Economicosy Transformacion , Prems Subramaniam , Marianoj Alvarez Darwinhealth , Mariano Alverez , Eugenef Douglass , Andrea Califano , Salud Carlos , Marianoj Alvarez , Columbia University Irving Medical Center , Vagelos College Of Physicians , Columbia Precision Oncology Initiative , National Cancer Institute , Catalan Institute Of Oncology , Us National Institutes Of Health , Federicom Giorgi University Of Bologna , School Of Arts , Bellvitge Institute For Biomedical Research , College Of Dental Medicine , Herbert Irving Comprehensive Cancer Center , Evano Paull Columbia University ,