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Loss of circadian regulation allows for increase in glucose production during lung cancer

Loss of circadian regulation allows for increase in glucose production during lung cancer
ANI |
Updated: Jun 28, 2021 08:15 IST
Washington [US], June 28 (ANI): New research from the University of California, Irvine reveals how the circadian regulation of glucose production in the liver is lost during lung cancer progression, and how the resulting increase in glucose production may fuel cancer cell growth.
The new study titled, Glucagon regulates the stability of REV-ERBa to modulate hepatic glucose production in a model of lung cancer-associated cachexia , was published in the journal Science Advances. It illustrates how the circadian clock is regulated under conditions of stress such as during lung cancer progression and cancer-associated tissue wasting disease called cachexia. ....

United States , Selma Masri , Kook Chun , University Of California , Department Of Biological Chemistry , School Of Medicine , Masri Laboratory , Biological Chemistry , Amandine Verlande , Sung Kook Chun , ஒன்றுபட்டது மாநிலங்களில் , செல்மா மஸ்ரி , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , துறை ஆஃப் உயிரியல் வேதியியல் , பள்ளி ஆஃப் மருந்து , உயிரியல் வேதியியல் ,

Health News | Loss of Circadian Regulation Allows for Increase in Glucose Production During Lung Cancer

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Washington [US], June 28 (ANI): New research from the University of California, Irvine reveals how the circadian regulation of glucose production in the liver is lost during lung cancer progression, and how the resulting increase in glucose production may fuel cancer cell growth.
The new study titled, Glucagon regulates the stability of REV-ERBa to modulate hepatic glucose production in a model of lung cancer-associated cachexia , was published in the journal Science Advances. It illustrates how the circadian clock is regulated under conditions of stress such as during lung cancer progression and cancer-associated tissue wasting disease called cachexia.
Our research shows that a critical circadian protein, REV-ERB, controls glucose production in the liver. During lung cancer progression and specifically under conditions of cachexia, this circadian regulation is lost, resulting in increased glucose production from the liver, said senior author Se ....

United States , Selma Masri , Kook Chun , University Of California , Department Of Biological Chemistry , School Of Medicine , Masri Laboratory , Biological Chemistry , Amandine Verlande , Sung Kook Chun , ஒன்றுபட்டது மாநிலங்களில் , செல்மா மஸ்ரி , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , துறை ஆஃப் உயிரியல் வேதியியல் , பள்ளி ஆஃப் மருந்து , உயிரியல் வேதியியல் ,

Loss of circadian regulation allows for increase in glucose production during lung cancer

New research from the University of California, Irvine reveals how the circadian regulation of glucose production in the liver is lost during lung cancer progression, and how the resulting increase in glucose production may fuel cancer cell growth. ....

United States , Selma Masri , Kook Chun , University Of California , Department Of Biological Chemistry , School Of Medicine , Concern Foundation , Masri Laboratory , National Institutes Of Health , Chao Family Comprehensive Cancer Center , Cancer Research Coordinating Committee , V Foundation For Cancer Research , Science Advances , Biological Chemistry , Amandine Verlande , Sung Kook Chun , National Institutes , Cancer Research , Family Comprehensive Cancer , Medicine Health , Circadian Rhythm , ஒன்றுபட்டது மாநிலங்களில் , செல்மா மஸ்ரி , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , துறை ஆஃப் உயிரியல் வேதியியல் , பள்ளி ஆஃப் மருந்து ,

Research shows how circadian control of glucose production is disrupted during lung cancer progression

New research from the University of California, Irvine reveals how the circadian regulation of glucose production in the liver is lost during lung cancer progression, and how the resulting increase in glucose production may fuel cancer cell growth. ....

United States , Selma Masri , Kook Chun , Emily Henderson , University Of California , Department Of Biological Chemistry , School Of Medicine , Masri Laboratory , Science Advances , Biological Chemistry , Amandine Verlande , Sung Kook Chun , Lung Cancer , ஒன்றுபட்டது மாநிலங்களில் , செல்மா மஸ்ரி , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா , துறை ஆஃப் உயிரியல் வேதியியல் , பள்ளி ஆஃப் மருந்து , உயிரியல் வேதியியல் ,