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We sat down with Mark Sundrud, PhD, to discuss bile acids and T cells in cholestatic liver disease and the future of research regarding the interplay between intestinal and liver functions. ....
‘X marks spot’ for Crohn’s breakthrough Study reveals possibility of new drug therapy A targeted treatment for people with Crohn’s disease could soon be available, according to new research. Crohn’s is an inflammatory bowel disease which can affect any part of the gut, from the mouth to the anus. Patients are typically treated with powerful anti-inflammatory medications that act throughout the body, not just in the digestive tract, creating the potential for unintended, and often serious, side-effects. Writing in the April 2021 edition of the journal et al said they found that certain immune cells in the small intestine have evolved a molecular sensing mechanism to protect themselves from the toxic effects of high bile acid concentrations in the small intestine. ....
Scripps Research immunologist Mark Sundrud, PhD, finds a new direction for Crohn s disease research lies in the interplay between bile acids and T cells in the small intestine. Credit: Scott Wiseman for Scripps Research. Read Time: People with Crohn s disease are typically treated with powerful anti-inflammatory medications that act throughout their body, not just in their digestive tract, creating the potential for unintended, and often serious, side effects. New research from the lab of Mark Sundrud, PhD, at Scripps Research, Florida suggests a more targeted treatment approach is possible. Crohn s disease develops from chronic inflammation in the digestive tract, often the small intestine. More than half a million people in the United States live with the disease, which can be debilitating and require repetitive surgeries to remove irreversibly damaged intestinal tissue. ....
Study offers localized treatment direction for a cause of Crohn s disease People with Crohn s disease are typically treated with powerful anti-inflammatory medications that act throughout their body, not just in their digestive tract, creating the potential for unintended, and often serious, side effects. New research from the lab of Mark Sundrud, PhD, at Scripps Research, Florida suggests a more targeted treatment approach is possible. Crohn s disease develops from chronic inflammation in the digestive tract, often the small intestine. More than half a million people in the United States live with the disease, which can be debilitating and require repetitive surgeries to remove irreversibly damaged intestinal tissue. ....
Crohn’s disease is a type of inflammatory bowel disease (IBD) that causes inflammation of the digestive tract. Anti-inflammatory medications can greatly reduce its signs and symptoms and even bring about long-term remission and healing of inflammation. However, medications do not just target the digestive tract; they can affect the entire body creating the potential for unintended side effects. Using a mouse model, researchers led by Mark Sundrud, PhD, associate professor, department of immunology and microbiology at Scripps Research, Florida, now suggest a more targeted treatment approach. Their findings are described in the journal “Bile acids are lipid-emulsifying metabolites synthesized in hepatocytes and maintained in vivo through enterohepatic circulation between the liver and small intestine,” wrote the researchers. “As detergents, bile acids can cause toxicity and inflammation in enterohepatic tissues. Nuclear receptors maintain bile acid homeostasis in he ....