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Mark Sundrud, PhD: Bile Acid and T Cell Interplay in Cholestatic Diseases

We sat down with Mark Sundrud, PhD, to discuss bile acids and T cells in cholestatic liver disease and the future of research regarding the interplay between intestinal and liver functions. ....

United States , Mark Sundrud , Geisel School Of Medicine At Dartmouth College , Geisel School , Dartmouth College , Gut Liver Axis , Therapeutic Target , Cholestatic Liver , Liver Meeting , American Association , Liver Diseases , T Cell , Bile Acid , Cholestatic Liver Disease ,

Save Your Liver Foundation launches 'Heal the gut-save the liver' campaign

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Greater Accra , Aweeba Azongo , Nyaaba Aweeba Azongo , Hepatitis Fund , Oliver Campaign , Ghana Health Service , International Press Centre , World Hepatitis Alliance , Save Your Liver Foundation , Saharan Africa , Gut Save The Liver , Ghana Liver Hepatitis Fund , Ghana Response , Gut Liver Axis ,

Frontiers | Lentinan Supplementation Protects the Gut–Liver Axis and Prevents Steatohepatitis: The Role of Gut Microbiota Involved

The microbiota-gut-liver axis has emerged as an important player in developing non-alcoholic steatohepatitis (NASH), a type of non-alcoholic fatty liver disease (NAFLD). Higher mushroom intake is negatively associated with the prevalence of NAFLD. This study examined whether lentinan, an active ingredient in mushroom, could improve NAFLD and gut microbiota dysbiosis in NAFLD mice induced by a high-fat (HF) diet. Dietary lentinan supplementation for 15 weeks significantly improved gut microbiota dysbiosis in HF mice, evidenced by increased the abundance of phylum Actinobacteria, and decreased phylum Proteobacteria and Epsilonbacteraeota. Moreover, lentinan improved intestinal barrier integrity, characterized by enhancing intestinal tight junction proteins, restoring intestinal redox balance, and reducing serum lipopolysaccharide (LPS). In the liver, lentinan attenuated HF diet-induced steatohepatitis, alteration of inflammation-insulin (NFκB-PTP1B-Akt-GSK3β) signaling molecules, and d ....

United States , South Korea , J Physiol Gastrointest , Clin Biochem , Wuy Mito , Nutr Biochem , Guj Fastp , Hasan Alkhatib , Physiol Biochem , Gastroenterol Hepatol , J Physiol Pharmacol , Biomed Pharmacother , Yux Lycium , Jiangsu Graduate Innovation Program No , Yuanye Biological Technology Co Ltd Shanghai , National Natural Science Foundation Of China , Foundation For Talents Of Xuzhou Medical University , Nucleic Acids Research , Jiangsu Shuangchuang Program , Capitalbio Technology Co Ltd China , Ethics Committee Of Xuzhou Medical University , Natural Science Foundation Of Jiangsu Province No , Illumina Hiseq , Tight Junction Proteins , Redox Imbalance , Signaling Pathway ,