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Researchers study iPSCs to uncover genetic causes of disease

Researchers study iPSCs to uncover genetic causes of disease
drugtargetreview.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from drugtargetreview.com Daily Mail and Mail on Sunday newspapers.

Marc Jan Bonder , Oliver Stegle , European Molecular Biology Laboratory , German Cancer Research Center , மார்க் ஜான் போண்டர் , ஐரோப்பிய மூலக்கூறு உயிரியல் ஆய்வகம் , ஜெர்மன் புற்றுநோய் ஆராய்ச்சி மையம் ,

Induced Pluripotent Stem Cells Reveal Causes of Disease

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Induced pluripotent stem cells (iPSC) are suitable for discovering the genes that underly complex and also rare genetic diseases. Scientists from the German Cancer Research Center (DKFZ) and the European Molecular Biology Laboratory (EMBL), together with international partners, have studied genotype-phenotype relationships in iPSCs using data from approximately one thousand donors.
Tens of thousands of tiny genetic variations (SNPs, single nucleotide polymorphisms) have been identified in the human genome that are associated with specific diseases. Many of these genetic variants are not located in the protein-coding regions of genes, but affect regulatory sections. Therefore, scientists are trying to find out if and in which tissues these variants can be linked to changes in the activity of specific genes. ....

Marc Jan Bonder , Nat Genet , Oliver Stegle , Wellcome Trust Sanger Institute , Stanford University , European Molecular Biology Laboratory , German Cancer Research Center , Nature Genetics , மார்க் ஜான் போண்டர் , நாட் ஜெநெட் , வெல்கம் நம்பிக்கை சாங்கர் நிறுவனம் , ஸ்டான்போர்ட் பல்கலைக்கழகம் , ஐரோப்பிய மூலக்கூறு உயிரியல் ஆய்வகம் , ஜெர்மன் புற்றுநோய் ஆராய்ச்சி மையம் , இயற்கை ஜெநெடிக்ஸ் ,

Induced pluripotent stem cells reveal causes of disease

Induced pluripotent stem cells reveal causes of disease
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

Baden Wüberg , Marc Jan Bonder , Oliver Stegle , German Cancer Research Center Deutsches Krebsforschungszentrum , Helmholtz Association Of German Research Centers , German Cancer Research Center , Diseases Network , Ministry Of Education , German Consortium For Translational Cancer Research , National Center , Hopp Children Tumor Center Ki , Cancer Information Service , European Molecular Biology Laboratory , Genesips Consortium , Wellcome Trust Sanger Institute , Pscore Consortium , Phlips Consortium , Hipsci Consortium , Stanford University , German Centers For Health Research , Nature Genetics , Undiagnosed Diseases Network , Deutsches Krebsforschungszentrum , Information Service , Tumor Diseases , Hopp Children ,

64 human genomes as new reference for global genetic diversity

64 human genomes as new reference for global genetic diversity
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

Baden Wüberg , Marc Jan Bonder , Udays Evani , Michaele Talkowski , Nelsont Chuang , Jana Ebler , Feyza Yilmaz , Aaronm Wenger , Yu Chen , Maryam Ghareghani , Jingwen Ren , Bernardo Rodriguez Martin , Peter Audano , Sushant Kumar , Markb Gerstein , Junjie Chen , Alexandrap Lewis , Katherinem Munson , Waynee Clarke , Allisona Regier , Tsung Yu Lu , Paul Flicek , Haleyj Abel , David Porubsky , Qihui Zhu , Patrick Hasenfeld ,