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POSEIDON: Two ICIs Plus Chemo Up Survival in mNSCLC

POSEIDON: Two ICIs Plus Chemo Up Survival in mNSCLC
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United States , Jill Feldman , Charu Aggarwal , Julier Brahmer , Leslyem Heisler , Melissal Johnson , Sidney Kimmel Comprehensive Cancer Center , Sarah Cannon Research Institute , World Conference , Lung Cancer , Johns Hopkins Medicine , Associate Professor , Lung Cancer Excellence , Penn Medicine , Eastern Europe ,

Immunotherapy alone extended life for metastatic lung cancer patients with KRAS mutation

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IMAGE: Charu Aggarwal, MD, MPH (top), Ronac Mamtani, MD, (bottom left), and Lova Sun, MD.
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Credit: Penn Medicine
PHILADELPHIA Real-word evidence is suggesting, for the first time, the most beneficial treatment courses that could help extend the lives of patients with metastatic non-small cell lung cancer, according to research from the
Abramson Cancer Center at the University of Pennsylvania.
In a new study published online today in
JAMA Oncology, researchers show that patients harboring a KRAS gene mutation with high levels of PDL-1 lived longer when treated with immunotherapy alone, compared to patients without this mutation. This survival difference by KRAS status was not seen, however, in patients treated with both chemotherapy and immunotherapy, suggesting combination therapy for patients without the mutation may be preferred. ....

University Of Pennsylvania , United States , Charu Aggarwal , Lova Sun , Rogerb Cohen , Coreyj Langer , Ronac Mamtani , Perelman School Of Medicine , Abramson Cancer Center , Flatiron Health , Perelman School , Associate Professor , Lung Cancer Excellence , Miles Tan , Medicine Health , Clinical Trials , பல்கலைக்கழகம் ஆஃப் பென்சில்வேனியா , ஒன்றுபட்டது மாநிலங்களில் , லோவா சூரியன் , பெரல்மேன் பள்ளி ஆஃப் மருந்து , பிளாட்டிரான் ஆரோக்கியம் , பெரல்மேன் பள்ளி , இணை ப்ரொஃபெஸர் , நுரையீரல் புற்றுநோய் சிறப்பானது , மருந்து ஆரோக்கியம் ,