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H3 acetylation selectively promotes basal progenitor proliferation and neocortex expansion science.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from science.org Daily Mail and Mail on Sunday newspapers.
SMART-Seq ® v4 Ultra Low Input RNA Kit from Takara Bio selectscience.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from selectscience.net Daily Mail and Mail on Sunday newspapers.
Abstract Alternative mRNA isoforms play a key role in generating diverse protein isoforms. To dissect isoform usage in the subcellular compartments of single cells, we introduced an novel approach, nanopore sequencing coupled with single-cell integrated nuclear and cytoplasmic RNA sequencing, that couples microfluidic fractionation, which separates cytoplasmic RNA from nuclear RNA, with full-length complementary DNA (cDNA) sequencing using a nanopore sequencer. Leveraging full-length cDNA reads, we found that the nuclear transcripts are notably more diverse than cytoplasmic transcripts. Our findings also indicated that transcriptional noise emanating from the nucleus is regulated across the nuclear membrane and then either attenuated or amplified in the cytoplasm depending on the function involved. Overall, our results provide the landscape that shows how the transcriptional noise arising from the nucleus propagates to the cytoplasm. ....
Modest contrast with weak black levels Oversaturated reds and undersaturated greens Sony is practically synonymous with quality TVs, and its new X900H family offers a stylish design, accurate colors out of the box, and loads of features thanks to the Android TV platform. It would be a strong choice for a budget-friendly line based on its performance. Unfortunately, it’s priced squarely in midrange territory, with the 55-inch XBR-55X900H we tested retailing for $999.99. That’s several hundred dollars more than stronger performers like the Hisense H9G and the TCL 6-Series. A Stylish Design The X900H looks simple and stylish, with a narrow matte black plastic bezel running around the screen, slightly wider on the bottom than on the sides and top. The bezel itself is framed by a band of brushed metal that curves around to flat, gunmetal sides. Along with thin, metal, V-shaped feet, the X900H gets a high-end-looking splash of chrome that doesn’t try to outshine th ....