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Long telomere syndrome is associated with an increased risk of developing neoplasms

1. In this case series, protection of telomeres 1 (POT1) mutations associated with long telomere length conferred an increased risk of developing benign and malignant solid neoplasms. 2. The risk of developing these neoplasms was mediated by extended cellular longevity. Evidence Rating Level: 1 (Excellent) Study Rundown: Telomere length is often predictive of the onset ....

Johns Hopkins University , Minute Medicine Inc , Rating Level , Telomere Length , Johns Hopkins Hospital Laboratories , Chronic Disease , Clonal Hematopoiesis , Extended Cellular Longevity , Long Telomere Syndrome , Pot1 Mutation ,

POT1-mediated long telomere syndrome is associated with familial clonal hematopoiesis

1. In this retrospective study, carriers with mutations in the gene encoding the protection of telomeres 1 protein (POT1) were found to have elongated telomeres compared to non-carrier relatives. 2. POT1 gene mutations were associated with a predisposition to a familial clonal hematopoiesis syndrome, increasing the risk of several neoplasms. Evidence Rating Level: 2 (Good) ....

Minute Medicine Inc , Rating Level , Chronic Disease , Chronic Lymphocytic Leukemia , Clonal Hematopoiesis , Familial Clonal Hematopoiesis , Long Telomere Syndrome , Pot1 Mediated Long Telomere Syndrome ,