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New Molecular Pathway Found Shared by Two Neurodegenerative Disorders

Amyotrophic lateral sclerosis and frontotemporal dementia are two neurodegenerative disorders in which many cases are linked by mislocalization of the TDP-43 protein, where instead of being located in the nucleus of the cell where genes are activated, it forms aggregates outside the nucleus in multiple neurodegenerative diseases. Rare mutations in TDP-43 are known to cause ALS, but almost all cases of ALS show mislocalization of TDP-43. ....

Pietro Fratta , Thomas Cheever , Len Petrucelli , Michael Ward , Aaron Gitler , National Institutes Of Health , Stanford University , National Institute Of Neurological Disorders , National Institute , Neurological Disorders , National Institutes , Mayo Clinic ,

Scientists discover new molecular pathway shared by two neurodegenerative disorders

Scientists discover new molecular pathway shared by two neurodegenerative disorders
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United States , Stanford University , United Kingdom , Pietro Fratta , Thomas Cheever , Len Petrucelli , Michael Ward , Aaron Gitler , Stanford University In , National Institutes Of Health , Intramural Research Program , National Institute On Aging , National Institute Of Neurological Disorders , National Institute , Neurological Disorders , National Institutes , Mayo Clinic ,