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Amivantamab Plus Chemotherapy with and without Lazertinib in EGFR-mutant NSCLC

1. Progression-free survival was 6.3 months for the amivantamab–chemotherapy group, 8.3 months for the amivantamab–lazertinib–chemotherapy group, and 4.2 months for the chemotherapy group. 2. Adverse events grade 3 or higher occurred in 72% vs 92% vs 48% respectively, with the most common adverse events being neutropenia, thrombocytopenia, anemia, and leukopenia Evidence Rating Level: 1 (Excellent) ....

Rating Level , Egfr Lung Cancer , Chronic Disease ,

COMING SOON: Amivantamab + Lazertinib Versus Osimertinib as 1L Treatment in EGFR-Mutated Advanced NSCLC: Primary Results From MARIPOSA

Expert oncologist Alex Spira, MD, PhD, FACP, shares his excitement for an upcoming program centered on the MARIPOSA study in advanced NSCLC following the ESMO 2023 annual meeting. ....

Lazertinib Versus Osimertinib , Mutated Advanced , Primary Results From , Non Small Cell Lung Cancer , Advanced Nsclc , Metastatic Nsclc , Mariposa Trial , Mariposa Study , Egfr Mutated , Egfr Mutant , Combination Therapy , Novel Therapy , Egfr Tki , Tyrosine Kinase Inhibitors , Met Inhibitor , Chrysalis Study , Chrysalis Trial , Exon 20 , Egfr L858r , Efficacy Data , Overall Survival , Progression Free Survival , Pfs Data , Cns Disease , Brain Metastases , Safety Data ,

Amivantamab Plus Lazertinib Improved PFS for EGFR-Mutated Advanced NSCLC

MARIPOSA demonstrated the combination reduced risk of progression or death by 30% compared with osimertinib. MARIPOSA-2 found amivantamab plus chemotherapy and amivantamab plus chemotherapy and lazertinib also improved progression-free survival (PFS) over chemotherapy after progression on osimertinib. ....

United States , Soult Ukpyolsi , South Korea , Republic Of Korea , Antonio Passaro , Byoung Chul Cho , Zofia Piotrowska , Yonsei University College Of Medicine , Harvard Medical School , European Institute Of Oncology , Yonsei Cancer Center , Division Of Thoracic Oncology , Harvard Medical School Zofia Piotrowska , Yonsei University College , Thoracic Oncology , European Institute , Massachusetts General Hospital , Esmo Congress ,

First-Line Amivantamab Plus Lazertinib Meets PFS End Point in EGFR+ NSCLC

First-line treatment with the combination of amivantamab and lazertinib resulted in a statistically significant and clinically meaningful improvement in progression-free survival compared with osimertinib in patients with locally advanced or metastatic non–small cell lung cancer harboring EGFR mutations. ....

United States , Alexander Spira , Peter Lebowitz , Virginia Cancer Specialists Research Institute , Lung Cancer , Dvanced Or Metastatic Non Small Cell Lung Cancer , Phase 3 Mariposa Trial ,

Amivantamab/Chemotherapy ± Lazertinib Improves PFS in Pretreated EGFR+ NSCLC

Amivantamab-vmjw plus carboplatin and pemetrexed, administered with or without lazertinib, significantly improved progression-free survival vs chemotherapy alone in patients with locally advanced or metastatic non–small cell lung cancer with EGFR exon 19 deletions or L858R substitutions after progression on or after osimertinib. ....

Peter Lebowitz , Janssen Research Development , Janssen Research , Small Cell Lung Cancer , Lung Cancer , Janssen Research Amp Development , Egfr Nsclc , Egfr Exon 19 Deletions Or L858r Substitution , Non Small Cell Lung Cancer , Phase 3 Mariposa 2 Trial Nct04988295 ,