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Amivantamab/Chemotherapy ± Lazertinib Improves PFS in Pretreated EGFR+ NSCLC

Amivantamab-vmjw plus carboplatin and pemetrexed, administered with or without lazertinib, significantly improved progression-free survival vs chemotherapy alone in patients with locally advanced or metastatic non–small cell lung cancer with EGFR exon 19 deletions or L858R substitutions after progression on or after osimertinib. ....

Peter Lebowitz , Janssen Research Development , Janssen Research , Small Cell Lung Cancer , Lung Cancer , Janssen Research Amp Development , Egfr Nsclc , Egfr Exon 19 Deletions Or L858r Substitution , Non Small Cell Lung Cancer , Phase 3 Mariposa 2 Trial Nct04988295 ,