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Scientists uncover new path toward treating a rare but deadly neurologic condition


BOSTON - Studies with a popular laboratory model, the nematode
Caenorhabditis elegans, have revealed a possible therapeutic avenue for a rare but deadly condition in which children are born without the ability to make molybdenum cofactor (Moco) on their own.
Though little known, Moco is essential for life and so far it has proven extremely difficult to stably isolate this compound in the laboratory, preventing its use as a therapeutic supplement. This new work, which appears in
Genes & Development, reveals that nematodes genetically engineered to be Moco-deficient can take up Moco that is attached to several types of proteins. This suggests that such protein-Moco complexes could be used as a treatment for Moco deficiency in people. ....

United States , Ralfr Mendel , Thomasw Hercher , Kurt Warnhoff , Gary Ruvkun , Department Of Genetics At Harvard Medical School , Department Of Molecular Biology , German Research Foundation , Braunschweig University Of Technology , Genes Development , National Institutes Of Health , Department Of Molecular Biology At Massachusetts , Molecular Biology , Massachusetts General Hospital , Harvard Medical , Braunschweig University , National Institutes , Damon Runyon , ஒன்றுபட்டது மாநிலங்களில் , துறை ஆஃப் ஜெநெடிக்ஸ் இல் ஹார்வர்ட் மருத்துவ பள்ளி , துறை ஆஃப் மூலக்கூறு உயிரியல் , ஜெர்மன் ஆராய்ச்சி அடித்தளம் , ப்ருன்ஸ்சவெய்க் பல்கலைக்கழகம் ஆஃப் தொழில்நுட்பம் , ஜீந்ஸ் வளர்ச்சி , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , துறை ஆஃப் மூலக்கூறு உயிரியல் இல் மாசசூசெட்ஸ் ,