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Scientists uncover new path toward treating a rare but deadly neurologic condition


BOSTON - Studies with a popular laboratory model, the nematode
Caenorhabditis elegans, have revealed a possible therapeutic avenue for a rare but deadly condition in which children are born without the ability to make molybdenum cofactor (Moco) on their own.
Though little known, Moco is essential for life and so far it has proven extremely difficult to stably isolate this compound in the laboratory, preventing its use as a therapeutic supplement. This new work, which appears in
Genes & Development, reveals that nematodes genetically engineered to be Moco-deficient can take up Moco that is attached to several types of proteins. This suggests that such protein-Moco complexes could be used as a treatment for Moco deficiency in people. ....

United States , Ralfr Mendel , Thomasw Hercher , Kurt Warnhoff , Gary Ruvkun , Department Of Genetics At Harvard Medical School , Department Of Molecular Biology , German Research Foundation , Braunschweig University Of Technology , Genes Development , National Institutes Of Health , Department Of Molecular Biology At Massachusetts , Molecular Biology , Massachusetts General Hospital , Harvard Medical , Braunschweig University , National Institutes , Damon Runyon , ஒன்றுபட்டது மாநிலங்களில் , துறை ஆஃப் ஜெநெடிக்ஸ் இல் ஹார்வர்ட் மருத்துவ பள்ளி , துறை ஆஃப் மூலக்கூறு உயிரியல் , ஜெர்மன் ஆராய்ச்சி அடித்தளம் , ப்ருன்ஸ்சவெய்க் பல்கலைக்கழகம் ஆஃப் தொழில்நுட்பம் , ஜீந்ஸ் வளர்ச்சி , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , துறை ஆஃப் மூலக்கூறு உயிரியல் இல் மாசசூசெட்ஸ் ,

Ancient DNA Reveals Genetic History of Caribbean World | Genetics, Paleoanthropology


In a new study of the genetic history of the pre-contact Caribbean, researchers analyzed genome-wide DNA data from 174 ancient individuals who lived in the Bahamas, Haiti and the Dominican Republic (collectively, Hispaniola), Puerto Rico, Curaçao and Venezuela, as well as the data from 89 previously sequenced ancient individuals.
Illustration of one of the early settlers in the Caribbean. Image credit: Tom Björklund.
Prior to European colonization, the Caribbean was a mosaic of distinct communities that were connected by networks of interaction since the first human occupations in Cuba, Hispaniola and Puerto Rico around 6,000 years ago.
The pre-contact Caribbean is divided into three archaeological ages, which denote shifts in material cultural complexes. ....

Puerto Rico , United States , Dominican Republic , Caribbean Sea , Belize General , Puerto Ricans , Kendra Sirak , William Keegan , David Reich , Department Of Genetics At Harvard Medical School , Blavatnik Institute At Harvard Medical School , University Of Florida , Florida Museum Of Natural History , Archaic Ages , Ceramic Age , Archaic Age , Florida Museum , Natural History , South Americans , North Americans , Central American , South America , Orinoco River Basin , Harvard Medical School , Human Evolutionary Biology , Professor David Reich ,