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New tool provides insight into the developmental history of certain immune cells

A new tool that can uncover the developmental history of certain immune cells is now freely available worldwide. The tool provides insights into the stages that immune cells go through in a healthy individual and how this can be impacted in disease. ....

United Kingdom , Sarah Teichmann , Lily Ramsey , Kelvin Zewen Tuong , Menna Clatworthy , Wellcome Sanger Institute , University Of Queensland , University Of Cambridge , Human Cell Atlas , Nature Biotechnology , Chenqu Suo , First Author , Wellcome Sanger , B Cell , Dwell Development , Genetic Recombination , Immune Response , Immune System , Natural Killer Cells , Single Cell Genomics ,

Differing immune reponses discovered in asymptomatic cases versus those with severe COVID-19 – Wellcome Sanger Institute

News Article by the Communications Team
20 Apr 2021
Using data from the Human Cell Atlas, researchers have identified the differences in immune cells’ response in those who had no symptoms compared to severe symptoms.
The largest study of its type in the UK has identified differences in the immune response to COVID-19, between people with no symptoms, compared to those suffering a more serious reaction to the virus.
Researchers from the Wellcome Sanger Institute, Newcastle University, University College London, University of Cambridge, EMBL’s European Bioinformatics Institute (EMBL-EBI) and their collaborators within the Human Cell Atlas initiative, found raised levels of specific immune cells in asymptomatic people. They also showed people with more serious symptoms had lost these protective cell types, but gained inflammatory cells. These differences in the immune response could help explain serious lung inflammation and blood ....

United Kingdom , City Of , Kelvin Zewen Tuong , Menna Clatworthy , Sarah Teichmann , John Marioni , Emuzlifah Haniffa , University College London , Cancer Research United Kingdom Cambridge Institute , Head Of Research , Human Cell Atlas Organising Committee , Wellcome Sanger Institute , Senior Group Leader , Wellcome Sanger Institute Associate Faculty , Newcastle University , University Of Cambridge , European Bioinformatics Institute , Clatworthy Lab , Human Cell Atlas , Bioinformatics Institute , Nature Medicine , Human Cell , Senior Clinical Fellow , Wellcome Sanger , Translational Immunology , Wellcome Sanger Institute Associate ,