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Menopause Is Finally Going Mainstream

After being ignored for decades, doctors, pharmaceutical companies, and startups are taking menopause treatment seriously. ....

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Is menopausal hormone therapy linked with dementia risk? Studies offer conflicting views

Is menopausal hormone therapy linked with dementia risk? Studies offer conflicting views
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HRT, Even Short-Term Use, Linked to Dementia Risk in Women

Short-term and cyclical use of estrogen and progestin therapy for menopausal symptoms is linked to an increased risk of dementia, results of a large, observational study suggest. ....

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Menopausal hormone therapy and dementia

A causal link remains unlikely

In a linked paper, Pourhadi and colleagues(doi:10.1136/bmj‑2022‑072770) investigated the associations of menopausal hormone therapy with dementia later in life.1 Their observational study of data from Danish national registries reported that hormone treatment was associated with an increased risk of dementia with either short term or long term use (risk of all cause dementia associated with exposure to oestrogen plus progestin v never use: hazard rate ratio of 1.24 (95% confidence interval of 1.17 to 1.35)). Alzheimer’s disease is twice as common in women than in men; therefore, midlife exposures that might influence its risk in women are of considerable interest.2

Menopausal hormone therapy has been in the spotlight as a potential risk factor contributing to this disparity in Alzheimer’s disease. Treatment was widely prescribed before the 2003 Women’s Health Initiative Memory Study (WHIMS) a randomised trial reported that oestrog ....

United States , Eli Lilly , Joanne Manson , Kejal Kantarci , Alzheimer Drug Discovery Foundation , National Institutes Of Health , Biogen Inc , American Menopause Society , Women Health Initiative Memory Study , Anne Manson , Health Initiative Memory Study , Younger Women , North American Menopause Society , Avid Radiopharmaceuticals , National Institutes , Drug Discovery Foundation ,

HRT use by younger women linked to dementia, study says. Experts disagree

(CNN) — Women in their 50s who took estrogen and progestin hormone replacement therapy for menopausal symptoms had an increased risk of dementia within 20 years, a new observational study ....

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