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Hopes Are High for the mRNA Technology that Is Leading Us Out of the Pandemic

Hopes Are High for the mRNA Technology that Is Leading Us Out of the Pandemic
spiegel.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from spiegel.de Daily Mail and Mail on Sunday newspapers.

New York , United States , United Kingdom , Stanford University , Yale School , New Jersey , Baden Wüberg , Martin Fussenegger , Lior Zangi , Elmar Kraus , Dirk Arnold , Zhiqiang Shu , Niels Halama , Ingmar Hoerr , Jona Wolff , Gaurav Sahay , Richard Weiss , Dietmar Hopp , Keiji Itaka , Richard Bucala , Department Of Biosystems Science , Paul Ehrlich Institute , Melinda Gates Foundation , University Of Salzburg , German Cancer Research Center , Institute Of Biomaterials ,

Nanotechnology Now - Press Release: A new agent for the brain diseases: mRNA

Nanotechnology Now
Home > Press > A new agent for the brain diseases: mRNA
Brain-derived neurotrophic factor (BDNF) serves as a potential candidate neuroprotective agent, but there are almost no successful clinical trials due to high hurdle in brain access and short half-life. Fukushima et al. show intraventriclarly administered BDNF mRNA using polyplex nanomicelle exerted a prominent effect to prevent neuronal death with the unique mechanism of action. BDNF mRNA was extensively introduced into the astrocytes to generate a higher level BDNF protein in ischemic lesion.
CREDIT
Department of Biofunction Research,TMDU
Abstract:
Researchers from Tokyo Medical and Dental University (TMDU) demonstrate an mRNA delivery system that effectively produces BDNF protein in rat ....

Keiji Itaka , Yuta Fukushima , Department Of Biofunction Research , Wave Inc , Home Press , Biofunction Research , Tokyo Medical , Dental University , Nanotechnology Now , அலை இன்க் , வீடு ப்ரெஸ் , டோக்கியோ மருத்துவ , டெஂடல் பல்கலைக்கழகம் , நானோ தொழில்நுட்பம் இப்போது ,

Novel mRNA delivery system produces a therapeutic protein that protects neurons from ischemia

Novel mRNA delivery system produces a therapeutic protein that protects neurons from ischemia
A lack of oxygen to brain tissue known as ischemia leads to the death of neurons, which results in stroke. Despite considerable research, there are currently no treatments that successfully prevent neuronal death. Now, Tokyo Medical and Dental University (TMDU) researchers have reported a way of delivering mRNA to produce a therapeutic protein that protects neurons. Their findings, demonstrated in rats, are published in
Biomaterials.
Brain-derived neurotrophic factor (BDNF) is a protein that enhances the survival and function of neurons. However, the BDNF molecule is too large to cross the brain s protective barrier and is rapidly removed from the central nervous system, making it difficult for BDNF to make its mark as a treatment. ....

Keiji Itaka , Yuta Fukushima , Emily Henderson , Tokyo Medical , Dental University , எமிலி ஹென்டர்சன் , டோக்கியோ மருத்துவ , டெஂடல் பல்கலைக்கழகம் ,

A new agent for the brain diseases: mRNA

A new agent for the brain diseases: mRNA
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

Keiji Itaka , Yuta Fukushima , Tokyo Medical , Dental University , டோக்கியோ மருத்துவ , டெஂடல் பல்கலைக்கழகம் ,