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Things to Do in September | Living | Metropolis Japan

Just because summer is over that doesn't mean festival time is finished for the year, heaps of great events are happening this month. ....

Taito Ku , Shinagawa Ku , Minato Ku , Mihama Ku , Japan General , Makuhari Messe , Roddy Ricch , Makuhari Messei , Ed Sheeran , Peggy Gou , Tanaka Masashi , Tokyo University Of Agriculture , Asakusa Samba , Tokyo City Flea , City Flea Market , Fall Festival , Musashino Hachimangu Shrine , Friday September , Science Exhibition , Dino Camp , Midtown Hall , Kenny Beats , Samba Carnival , Asakusa Samba Carnival , Junzaburo Ban , Game Show ,

What's Happening in Tokyo This March? | Living

Spring is just around the corner. Kick away the winter blues by going out and discover what is happening this March 2022. ....

Japan General , France General , United Kingdom , Ondulatoire Kotaro Nukaga , Mega Illumi , Damien Hirst , Gentaro Ishizuka Ondulatoire , Fondazione Prada , National Art Center , Mori Art Museum , Atami Plum Garden , Shizuoka Prefecture , Plum Blossom Festival , Magazine Tokyo , Antique Market , Akasaka Antique , Metropolis Magazine Tokyo , Live Music Venue , Incomplete Circle , Dragon Dance Metropolis Magazine Tokyo , Golden Dragon Dance , Metropolis Magazine , Pom Metropolis Magazine , Mori Art , Gestural Abstraction ,

Ultra-small nanomedicines which stably deliver oligonucleotides to refractory cancers

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VIDEO: Nanomedicines consisting of one molecule of oligonucleotide and one or two
molecules of Y-shaped block copolymer(s), of which the size is approximately
18 nm and is in dynamic equilibrium with free Y-shaped.
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Credit: 2021 Innovation Center of NanoMedicine
Summary
Ultra-small nanomedicines of approximately 18 nm were fabricated by dynamic ion-pairing between Y-shaped block copolymers and nucleic acid drugs, such as siRNA and antisense drugs.
Chemically modified and double-stranded oligonucleotides dramatically enhanced the stability of the ultra-small nanomedicines in the blood circulation.
The ultra-small size allows for high permeability in cancer tissues by slipping through the cracks in tumor vasculatures and stromal tissues. ....

Kanjiro Miyata , Mami Satake , Kazunori Kataoka , Makoto Shimazaki , King Skyfront , Department Of Material Engineering , Nature Communications , Innovation Network For Smart Health , Innovation Center , Innovation Program , Technology Agency , School Of Engineering , University Of Tokyo , Public Interest Incorporated Foundation , Research Promotion Office Person , Ministry Of Education , Controlled Release , Director General , Unit Polyion Complex , Material Engineering , Graduate School , Kawasaki City , Japan Science , Open Innovation Network , Smart Health , Promotion Office ,