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Nanomedicine activation profile determines efficacy depending on tumor c-Myc expression

It is known that c-Myc is involved in cancer cell proliferation and angiogenesis and changes the cell cycle, suppresses normal cell differentiation, and promotes cancer metastasis. It is a typical proto-oncogene that regulates many genes related to growth factors and is known to be involved in developing of many cancers, such as chromosomal translocation in Burkitt lymphoma. Therefore, drug discovery research is being conducted worldwide as an anticancer drug targeting this transcription factor that can directly attack cancer stem cells. However, since embryonic lethality occurs in c-Myc knockout mice, c-Myc is considered as an essential gene for living cells, and selective delivery to cancer tissues is an important key to developing its inhibitors. Besides, c-Myc is also known as a factor necessary for the initial induction of iPS cells. In the future this inhibition can be expected to be applied as a technology that can also be used to suppress iPS cell-derived carcinogenesis. ....

Tatsuya Yamasoba , Ryo Miyake , Kazunori Kataoka , Makoto Shimazaki , Horacio Cabral , King Skyfront , Ryu Matsumoto , Mami Satake , Innovation Network For Smart Health , Innovation Center , Department Of Bioengineering Prof , Innovation Program , Technology Agency , University Of Tokyo , Public Interest Incorporated Foundation , Research Promotion Office Person , Ministry Of Education , Director General , Impact Factor , Neck Surgery , Kawasaki City , Japan Science , Open Innovation Network , Smart Health , Promotion Office , ரியோ மியையாக்ய் ,

Ultra-small nanomedicines which stably deliver oligonucleotides to refractory cancers

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VIDEO: Nanomedicines consisting of one molecule of oligonucleotide and one or two
molecules of Y-shaped block copolymer(s), of which the size is approximately
18 nm and is in dynamic equilibrium with free Y-shaped.
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Credit: 2021 Innovation Center of NanoMedicine
Summary
Ultra-small nanomedicines of approximately 18 nm were fabricated by dynamic ion-pairing between Y-shaped block copolymers and nucleic acid drugs, such as siRNA and antisense drugs.
Chemically modified and double-stranded oligonucleotides dramatically enhanced the stability of the ultra-small nanomedicines in the blood circulation.
The ultra-small size allows for high permeability in cancer tissues by slipping through the cracks in tumor vasculatures and stromal tissues. ....

Kanjiro Miyata , Mami Satake , Kazunori Kataoka , Makoto Shimazaki , King Skyfront , Department Of Material Engineering , Nature Communications , Innovation Network For Smart Health , Innovation Center , Innovation Program , Technology Agency , School Of Engineering , University Of Tokyo , Public Interest Incorporated Foundation , Research Promotion Office Person , Ministry Of Education , Controlled Release , Director General , Unit Polyion Complex , Material Engineering , Graduate School , Kawasaki City , Japan Science , Open Innovation Network , Smart Health , Promotion Office ,