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Effectiveness of conservative management versus laparoscopic cholecystectomy in the prevention of recurrent symptoms and complications in adults with uncomplicated symptomatic gallstone disease (C-GALL trial): pragmatic, multicentre randomised controlled…

Objective To assess the clinical and cost effectiveness of conservative management compared with laparoscopic cholecystectomy for the prevention of symptoms and complications in adults with uncomplicated symptomatic gallstone disease.

Design Parallel group, pragmatic randomised, superiority trial.

Setting 20 secondary care centres in the UK.

Participants 434 adults (>18 years) with uncomplicated symptomatic gallstone disease referred to secondary care, assessed for eligibility between August 2016 and November 2019, and randomly assigned (1:1) to receive conservative management or laparoscopic cholecystectomy.

Interventions Conservative management or surgical removal of the gallbladder.

Main outcome measures The primary patient outcome was quality of life, measured by area under the curve, over 18 months using the short form 36 (SF-36) bodily pain domain, with higher scores (range 0-100) indicating better quality of life. Other outcomes included cos ....

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Experts explain why you need to winter-proof your sleep - and how

Experts explain why you need to winter-proof your sleep - and how
nottinghampost.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from nottinghampost.com Daily Mail and Mail on Sunday newspapers.

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Experts say you need to winter-proof your sleep - here's how

Experts say you need to winter-proof your sleep - here's how
walesonline.co.uk - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from walesonline.co.uk Daily Mail and Mail on Sunday newspapers.

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Do you need to winter-proof your sleep? Experts explain how

From festive parties and booze to seasonal stress, this time of year can leave us short on quality slumber. By Abi Jackson. ....

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Experts explain the reason why you should be 'winter-proofing' your sleep

Experts explain the reason why you should be 'winter-proofing' your sleep
dailyrecord.co.uk - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from dailyrecord.co.uk Daily Mail and Mail on Sunday newspapers.

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