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Orion Research Foundation is awarding EUR 1 million in

PRESS RELEASE 27 OCTOBER 2022 AT 8.00 a.m. EEST Orion Research Foundation is awarding EUR 1 million in grants and two EUR 100,000. ....

Eteläuomen Läi , Anders Jahre Young , Tiina Sikanen , Terhi Ormio , Jukka Westermarck , Hannes Lohi , Mikko Niemi , Turku Bioscience Centre , University Of Helsinki , Aalto University , Institute Of Biomedicine , Division Of Pharmaceutical Chemistry , Orion Corporation , Orion Research Foundation , Department Of Medical Biochemistry , Finnish Medical Society Duodecim , University Of Turku , Board Of The Research Foundation , Academy Of Finland , Academy Professor Johanna Ivaska , Research Foundation , Associate Professor Tiina Sikanen , Pharmaceutical Chemistry , Cancer Biology Jukka Westermarck , Pharmacogenetics Mikko Niemi , Associate Professor ,

Orion Oyj: Orion Research Foundation is awarding EUR 1 million in grants and two EUR 100,000 special grants today

PRESS RELEASE 27 OCTOBER 2022 AT 8.00 a.m. EEST Orion Research Foundation is awarding EUR 1 million in grants and two EUR 100,000 special grants today The Board of Directors ....

Eteläuomen Läi , Anders Jahre Young , Tiina Sikanen , Terhi Ormio , Jukka Westermarck , Hannes Lohi , Mikko Niemi , Turku Bioscience Centre , University Of Helsinki , Aalto University , Institute Of Biomedicine , Division Of Pharmaceutical Chemistry , Orion Corporation , Orion Research Foundation , Department Of Medical Biochemistry , Finnish Medical Society Duodecim , University Of Turku , Board Of The Research Foundation , Academy Of Finland , Academy Professor Johanna Ivaska , Research Foundation , Associate Professor Tiina Sikanen , Pharmaceutical Chemistry , Cancer Biology Jukka Westermarck , Pharmacogenetics Mikko Niemi , Associate Professor ,

Investegate |Orion Oyj Announcements | Orion Oyj: Orion Research Foundation is awarding EUR 1 million in grants and two EUR 100,000 special grants today

Investegate announcements from Orion Oyj, Orion Research Foundation is awarding EUR 1 million in grants and two EUR 100,000 special grants today ....

Eteläuomen Läi , Anders Jahre Young , Tiina Sikanen , Terhi Ormio , Jukka Westermarck , Hannes Lohi , Mikko Niemi , Turku Bioscience Centre , University Of Helsinki , Aalto University , Institute Of Biomedicine , Division Of Pharmaceutical Chemistry , Orion Corporation , Orion Research Foundation , Department Of Medical Biochemistry , Finnish Medical Society Duodecim , University Of Turku , Board Of The Research Foundation , Academy Of Finland , Academy Professor Johanna Ivaska , Research Foundation , Associate Professor Tiina Sikanen , Pharmaceutical Chemistry , Cancer Biology Jukka Westermarck , Pharmacogenetics Mikko Niemi , Associate Professor ,

Fundamental mechanism discovered that fine-tunes gene expression & is disrupted in cancer

Credit: The Wistar Institute
PHILADELPHIA and MELBOURNE, Australia (May. 17, 2021) A team of scientists from The Wistar Institute in Philadelphia and the Peter MacCallum Cancer Center in Melbourne, Australia, discovered a new checkpoint mechanism that fine-tunes gene transcription. As reported in a study published in
Cell, a component of the Integrator protein complex tethers the protein phosphatase 2A (PP2A) to the site of transcription allowing it to stop the activity of the RNA polymerase II enzyme (RNAPII). Disruption of this mechanism leads to unrestricted gene transcription and is implicated in cancer.
The study points to new viable opportunities for therapeutic intervention demonstrating the anti-cancer effect of a new combination treatment in preclinical models of solid and hematopoietic malignancies. ....

New York , United States , Dana Farber Cancer Institute , New South Wales , Benjamin Blyth , Otto Kauko , Jenniferr Devlin , Saraha Welsh , Elisa Barbieri , Kaylenej Simpson , Edwind Hawkins , Michael Ohlmeyer , Deboraha Knight , Matteo Costacurta , Stefan Bjelosevic , Gareth Gregory , Simonj Hogg , Ricky Johnstone , Elena Demosthenous , Magnus Zethoven , Jarrodj Sandow , Benp Martin , Conorj Kearney , Izabela Todorovski , Joseph Ha Vissers , Madisonj Kelly ,