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Study reveals genetic chain reaction that drives the spread of prostate cancer

RICHMOND, Va. — New research from scientists at VCU Massey Comprehensive Cancer Center and the VCU Institute of Molecular Medicine (VIMM) determined that a particular gene — MDA-9/Syntenin-1/SDCBP — is ....

Eesha Madan , Nitai Mukhopadhyay , Devanand Sarkar , Jolene Windle , Praveen Bhoopathi , Padmanabhan Mannangatti , Swadeshk Das , Webster Cavenee , Santanu Maji , D Joshua Cohen , Thelma Newmeyer Corman , Bryce Hatfield , Mark Subler , Julius Nyalwidhe , O John Semmes , Paulb Fisher , Rajan Gogna , Michael Levit , Xiang Yang Wang , Anjank Pradhan , Chunqing Guo , Amit Kumar , Department Of Human , Massey Comprehensive Cancer Center , Cancer Center Support Grant , Cancer Research At Massey ,

Study reveals genetic chain reaction that drives the spread of prostate cancer

RICHMOND, Va. — New research from scientists at VCU Massey Comprehensive Cancer Center and the VCU Institute of Molecular Medicine (VIMM) determined that a particular gene — MDA-9/Syntenin-1/SDCBP — is ....

Bryce Hatfield , Rajan Gogna , Jolene Windle , Webster Cavenee , Michael Levit , D Joshua Cohen , Paulb Fisher , Eesha Madan , Julius Nyalwidhe , Xiang Yang Wang , Thelma Newmeyer Corman , Anjank Pradhan , Padmanabhan Mannangatti , Praveen Bhoopathi , Devanand Sarkar , Chunqing Guo , Santanu Maji , Mark Subler , Amit Kumar , Swadeshk Das , O John Semmes , Nitai Mukhopadhyay , Department Of Human , Cancer Center Support Grant , College Of Engineering , University Of San Diego School Medicine ,

Researchers find strong evidence for testing VCU-manufactured drug in liver cancer

Researchers find strong evidence for testing VCU-manufactured drug in liver cancer
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United States , Rebecca Martin , Zhao Lai , Jinze Liu , Thelma Newmeyer Corman , Mark Subler , Debashri Manna , Nitai Mukhopadhyay , Jolene Windle , Mikhail Dozmorov , Paul Fisher , Carmen Camarena , Swadesh Das , Devanand Sarkar , Rachel Mendoza , Saranya Chidambaranathan Reghupaty , Jennifer Koblinski , Cancer Research At Massey , School Of Medicine , Institute Of Molecular Medicine , Department Of Human , Ut Health San Antonio , Dianne Wright Center , Harrison Foundation Distinguished Professorship In Cancer Research , Translational Research , Massey Cancer Center ,

Engineering T cells to attack cancer broadly

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IMAGE: Control mice (left panel) with prostate cancer show large areas of metastasis in the lungs (blue). When a subset of animals were treated with unmodified T cells (middle panel), the.
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Credit: Shawn Wang, Ph.D.
Through T cell engineering, researchers at Virginia Commonwealth University Massey Cancer Center show that it s possible to arrest tumor growth for a variety of cancers and squash the spread of cancer to other tissues. This research will be published in tomorrow s print edition of
Cancer Research.
The paper builds on decades of research by study co-senior author Paul B. Fisher, M.Ph., Ph.D., a member of Massey s Cancer Biology research program, who discovered a protein called IL-24 that attacks a variety of cancers in several different ways. ....

Ranjan Pradhan , Jolene Windle , Chunqing Guo , Zheng Liu , Xiaofei Yu , Xiang Yang Shawn Wang , Shixian Chen , Swadesh Das , Xia Li , Wenjie Liu , Thelma Newmeyer Corman , Paulb Fisher , Masoud Manjili , Massey Cancer Center Research Development Funds , School Of Medicine , National Cancer Institute , Institute Of Molecular Medicine , Department Of Human , Oncology Research , Virginia Commonwealth University Massey Cancer Center , Cancer Research , National Foundation For Cancer Research , Massey Cancer Center , Department Of Defense Prostate Cancer Research Program , Cancer Center Support Grant , Cancer Biology ,

Scientists identify protein that could serve as a therapeutic target in lung cancer

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Scientists at VCU Massey Cancer Center have identified a protein that operates in tandem with a specific genetic mutation to spur lung cancer growth and could serve as a therapeutic target to treat the disease.
Mutations in the p53 gene are found in more than half of all cancers, but it remains difficult to effectively target the gene with drugs even decades after its discovery. Though previous research has shown that p53 acts as a tumor suppressor and initiates cancer cell death in its natural state, a new study led by Sumitra Deb, Ph.D., suggests that gain-of-function (GOF) mutations a type of mutation where the changed gene has an added function turn p53 into an oncogene, causing cells to replicate uncontrollably and contribute to cancer development. ....

United States , Elizabeth Fry , Jolene Windle , Sumitra Deb , Brad Windle , Andrew Yeudall , Kazushi Inoue , Swati Deb , Shilpa Singh , Catherine Vaughan , Raghavendra Pillappa , Mark Subler , Steven Grossman , Nature Communications , School Of Medicine , Norris Comprehensive Cancer Center , Georgia Cancer Center At Augusta University , Department Of Biochemistry , Massey Cancer Center , Wake Forest University School Of Medicine , Cancer Center , Cancer Biology , Molecular Biology , Comprehensive Cancer Center , Georgia Cancer Center , Augusta University ,