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Protein Inhibition Creates Inhospitable Environment for Aggressive Breast Tumors

Protein Inhibition Creates Inhospitable Environment for Aggressive Breast Tumors
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Sarah Spiegel , Melissa Maczis , Michael Maceyka , Christopher Green , Sheldon Milstien , Mikhail Dozmorov , Cynthia Weigel , Shawn Wang , Chunqing Guo , Elisa Palladino , Uf Health , Department Of Biochemistry , Cancer Research , School Of Medicine , Massey Cancer Center , Cancer Center , Cancer Biology , Molecular Biology ,

Engineering T cells to attack cancer broadly


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IMAGE: Control mice (left panel) with prostate cancer show large areas of metastasis in the lungs (blue). When a subset of animals were treated with unmodified T cells (middle panel), the.
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Credit: Shawn Wang, Ph.D.
Through T cell engineering, researchers at Virginia Commonwealth University Massey Cancer Center show that it s possible to arrest tumor growth for a variety of cancers and squash the spread of cancer to other tissues. This research will be published in tomorrow s print edition of
Cancer Research.
The paper builds on decades of research by study co-senior author Paul B. Fisher, M.Ph., Ph.D., a member of Massey s Cancer Biology research program, who discovered a protein called IL-24 that attacks a variety of cancers in several different ways. ....

Ranjan Pradhan , Jolene Windle , Chunqing Guo , Zheng Liu , Xiaofei Yu , Xiang Yang Shawn Wang , Shixian Chen , Swadesh Das , Xia Li , Wenjie Liu , Thelma Newmeyer Corman , Paulb Fisher , Masoud Manjili , Massey Cancer Center Research Development Funds , School Of Medicine , National Cancer Institute , Institute Of Molecular Medicine , Department Of Human , Oncology Research , Virginia Commonwealth University Massey Cancer Center , Cancer Research , National Foundation For Cancer Research , Massey Cancer Center , Department Of Defense Prostate Cancer Research Program , Cancer Center Support Grant , Cancer Biology ,