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Study reveals role of neutrophil lipid transfer in lung cancer transition

Phenotypic plasticity is a cancer hallmark, and lung adeno-to-squamous transition (AST) triggered by LKB1 inactivation is significantly associated with drug resistance. Clinical data show that squamous transition occurs in certain lung adenocarcinoma patients who relapse from targeted therapy using EGFR tyrosine-kinase inhibitors (TKIs) or KRAS inhibitor. However, the epigenetic regulatory mechanisms involved in AST remain largely unknown. ....

Ji Hongbin , Yun Xue , Shanghai Institute Of Biochemistry , Shanghai Medical College Of Fudan University , Experimental Medicine , Molecular Cell Science , Shanghai Institute , Cell Biology , Chinese Academy , Shanghai Medical College , Fudan University ,

Proteogenomics reveal prognostic markers of small cell lung cancer, advance development of precision therapies

Proteogenomics reveal prognostic markers of small cell lung cancer, advance development of precision therapies
medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.

Zhang Peng , Qian Liu , Ji Hongbin , Gao Daming , Shanghai Pulmonary Hospital Of The Tongji University , Shanghai Institute Of Biochemistry , Shanghai Pulmonary Hospital , Tongji University , Shanghai Institute , Materia Medica , Chinese Academy , Molecular Cell Science , Cell Biology ,