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Study reveals role of neutrophil lipid transfer in lung cancer transition

Phenotypic plasticity is a cancer hallmark, and lung adeno-to-squamous transition (AST) triggered by LKB1 inactivation is significantly associated with drug resistance. Clinical data show that squamous transition occurs in certain lung adenocarcinoma patients who relapse from targeted therapy using EGFR tyrosine-kinase inhibitors (TKIs) or KRAS inhibitor. However, the epigenetic regulatory mechanisms involved in AST remain largely unknown.

Ji hongbinYun xueShanghai institute of biochemistryShanghai medical college of fudan universityExperimental medicineMolecular cell scienceShanghai instituteCell biologyChinese academyShanghai medical collegeFudan university

Study sheds light on how androgens shape sex differences at the cellular and molecular levels

Sex differences are widespread across human development, physiological processes, and diseases, making it important to characterize the impact of sex differences in these areas.

Shanghai institute of biochemistryChinese academy of sciencesShenzhen bay laboratoryChinese academy of sciences headquartersMolecular cell scienceShanghai instituteCell biologyChinese academyPeking universityUnited kingdom biobank

Sex-Biased Disease Targets Found in Single-Cell and UK Biobank Data Merge

Sex-Biased Disease Targets Found in Single-Cell and UK Biobank Data Merge
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Institute of cancer researchShanghai institute of biochemistryShenzhen bay laboratoryShanghai instituteCell biologyChinese academyCancer researchUnited kingdom biobank

Scientists Probe Androgens Impact on Sex Differences

Scientists Probe Androgens Impact on Sex Differences
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Shenzhen bay laboratoryShanghai institute of biochemistryMolecular cell scienceShanghai instituteCell biologyChinese academyPeking universityUnited kingdom biobank

Researchers explore role of androgens in shaping sex differences

Researchers explore role of androgens in shaping sex differences
medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.

Yu chenGao dongChen luonanShenzhen bay laboratoryShanghai institute of biochemistryMolecular cell scienceShanghai instituteCell biologyChinese academyBai fanPeking universityUnited kingdom biobank