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Scientists make pivotal discovery on mechanism of Epstein-Barr virus latent infection


Credit: The Wistar Institute
PHILADELPHIA (Jan. 21, 2021) Researchers at The Wistar Institute have discovered a new enzymatic function of the Epstein-Barr Virus (EBV) protein EBNA1, a critical factor in EBV s ability to transform human cells and cause cancer. Published in
Cell, this study provides new indications for inhibiting EBNA1 function, opening up fresh avenues for development of therapies to treat EBV-associated cancers.
EBV establishes life-long, latent infection in B lymphocytes, which can contribute to development of different cancer types, including Burkitt s lymphoma, nasopharyngeal carcinoma (NPC) and Hodgkin s lymphoma.
The Epstein-Barr Nuclear Antigen 1 (EBNA1) serves as an attractive therapeutic target for these cancers because it is expressed in all EBV-associated tumors, performs essential activities for tumorigenesis and there are no similar proteins in the human body. ....

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