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Age and Ferritin Levels May Predict MIS-C Severity

Children older than 5 years and those with ferritin levels greater than 500 μg/L had greater risk of severe illness in MIS-C in a multinational study. ....

United States , Costa Rica , Adrienne Randolph , Joan Robinson , University Of Alberta , Jolla Pharmaceutical Company , Pediatric Investigators Collaborative Network On Infections , Harvard Medical School , Janeway Foundation Research Grant , Canadian Medical Association Journal , Medscape Medical , Canadian Medical Association , Pediatric Investigators Collaborative Network , Medscape Medical News , Intensive Care Unit Icu , Intensive Care Unit , Intensive Care , 019 Novel Coronavirus , 019 Ncov , Uhan Coronavirus , Uman Coronavirus Hku1 , Uman Coronavirus Oc43 , Cov Oc43 , Uman Coronavirus 229e , Cov 229e , Heat Exhaustion ,

Predictors of severe illness in children with multisystem inflammatory syndrome after SARS-CoV-2 infection: a multicentre cohort study

Background: SARS-CoV-2 infection can lead to multisystem inflammatory syndrome in children (MIS-C). We sought to investigate risk factors for admission to the intensive care unit (ICU) and explored changes in disease severity over time.

Methods: We obtained data from chart reviews of children younger than 18 years with confirmed or probable MIS-C who were admitted to 15 hospitals in Canada, Iran and Costa Rica between Mar. 1, 2020, and Mar. 7, 2021. Using multivariable analyses, we evaluated whether admission date and other characteristics were associated with ICU admission or cardiac involvement.

Results: Of 232 children with MIS-C (median age 5.8 yr), 130 (56.0%) were male and 50 (21.6%) had comorbidities. Seventy-three (31.5%) patients were admitted to the ICU but none died. We observed an increased risk of ICU admission among children aged 13–17 years (adjusted risk difference 27.7%, 95% confidence interval [CI] 8.3% to 47.2%), those aged 6–12 years (adjusted risk ....

Costa Rica , United States , Dara Petel , Sarah Tehseen , Jared Bullard , Michelle Barton , Peter Gill , Marie Astrid Lefebvre , E Ann Yeh , Sanofi Pasteur , Shaun Morris , Ali Manafi , Joan Robinson , Alison Lopez , Tammie Dewan , Rupeena Purewal , Jesse Papenburg , Kirk Leifso , Janell Lautermilch , Adriana Yock Corrales , Jacqueline Wong , Ashley Roberts , Nicole Le Saux , Rolando Ulloa Gutierrez , Suzette Cooke , Marcela Hernandezde Mezerville ,