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Predictors of severe illness in children with multisystem inflammatory syndrome after SARS-CoV-2 infection: a multicentre cohort study

Background: SARS-CoV-2 infection can lead to multisystem inflammatory syndrome in children (MIS-C). We sought to investigate risk factors for admission to the intensive care unit (ICU) and explored changes in disease severity over time.

Methods: We obtained data from chart reviews of children younger than 18 years with confirmed or probable MIS-C who were admitted to 15 hospitals in Canada, Iran and Costa Rica between Mar. 1, 2020, and Mar. 7, 2021. Using multivariable analyses, we evaluated whether admission date and other characteristics were associated with ICU admission or cardiac involvement.

Results: Of 232 children with MIS-C (median age 5.8 yr), 130 (56.0%) were male and 50 (21.6%) had comorbidities. Seventy-three (31.5%) patients were admitted to the ICU but none died. We observed an increased risk of ICU admission among children aged 13–17 years (adjusted risk difference 27.7%, 95% confidence interval [CI] 8.3% to 47.2%), those aged 6–12 years (adjusted risk ....

Costa Rica , United States , Dara Petel , Sarah Tehseen , Jared Bullard , Michelle Barton , Peter Gill , Marie Astrid Lefebvre , E Ann Yeh , Sanofi Pasteur , Shaun Morris , Ali Manafi , Joan Robinson , Alison Lopez , Tammie Dewan , Rupeena Purewal , Jesse Papenburg , Kirk Leifso , Janell Lautermilch , Adriana Yock Corrales , Jacqueline Wong , Ashley Roberts , Nicole Le Saux , Rolando Ulloa Gutierrez , Suzette Cooke , Marcela Hernandezde Mezerville ,

Sask. task force struck to stop spread of syphilis


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Of all the diseases Dr. Rupeena Purewal was watching, syphilis was never at the top of the list.
But the Saskatoon pediatric infectious disease doctor says the surging case numbers across Western Canada have suddenly made the disease an emerging issue, particularly for newborn children if their mother is infected during pregnancy.
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Sask. task force struck to stop spread of syphilis Back to video
She is now part of a provincial task force of doctors, nurses and public health experts trying get a handle on the disease, which she notes is entirely preventable and treatable but can often go unseen. ....

Savannah Holt , Vanessa Poliquin , Zak Vescera , Albert Jimmy , Rupeena Purewal , Ibrahim Khan , Saskatoon Starphoenix , Postmedia Network Inc , Public Health Agency Of Canada , Ministry Of Health , Saskatchewan Prevention Institute , Saskatchewan Ministry Of Health , University Of Manitoba , Matt Smith , Western Canada , Public Health Agency , Onion Lake Cree Nation , Afternoon Headlines , Postmedia Network , Street East , சவன்னா ஹோல்ட் , ஆல்பர்ட் ஜிம்மி , இப்ராஹிம் காந் , அமைச்சகம் ஆஃப் ஆரோக்கியம் , சஸ்காட்செவன் ப்ரெவெந்ஶந் நிறுவனம் , சஸ்காட்செவன் அமைச்சகம் ஆஃப் ஆரோக்கியம் ,