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Lupus Nephritis: Hopes, Questions Arise for Baricitinib

Results from a small, independently funded, double-blind, active-comparator trial suggest that baricitinib could be beneficial in the treatment of lupus nephritis. ....

United States , South Australia , Ericf Morand , Manal Hassanien , Eli Lilly , European Alliance Of Associations , Therapeutics Department At Assiut University , Monash Health Rheumatology Unit , Rheumatology Research , European Alliance , Advanced Therapeutics Department , Assiut University , Systemic Lupus Erythematosus , Lupus Nephritis , Jak Stat , Ak Stat Signaling Pathway , Ak Stat Cytokine Receptors , End Stage Renal Disease Esrd , End Stage Renal Disease , Rheumatoid Arthritis , Alopecia Areata ,

Meta-Analysis Probes Cancer Risk Concern for JAK Inhibitors

Although no increased cancer risk was seen vs methotrexate or placebo, Janus kinase inhibitors were associated with a higher cancer risk than were tumor necrosis factor inhibitors in a meta-analysis. ....

United Kingdom , City Of , Christopher Stovin , Anurag Bharadwaj , Essex Foundation , Princess Royal University Hospital , British Society For Rheumatology , King College Hospital , Drug Administration , British Society , College Hospital , Medscape Medical , Basildon Hospital , South Essex Foundation Trust , Rheumatoid Arthritis , Biologic Therapy , Cancer Risk , Alignant Neoplasia , Jak Stat , Ak Stat Signaling Pathway , Ak Stat Cytokine Receptors , Anti Tnf , Anti Tumor Necrosis Factor , Meta Analysis , Ankylosing Spondylitis , Psoriatic Arthritis ,

Cytokines Play Integral Role in Cancer Immune Cycle

In the setting of cancer, cytokines contribute to cells’ antitumor response, cell damage, inflammation, angiogenesis, metastasis, and other cellular processes that enable tumor survival ....

Updated August , Spring Harb Perspect , Des Devel , Precision Medicine , Jak Stat , Helpert Cells , Antitumor Immune Response , Immune System ,

EMA Issues Positive Opinion on the Safety of Filgotinib

The EMA has issued a positive opinion of the type II variation application of the JAK1 inhibitor filgotinib, based on testicular function safety data from two phase 2 clinical trials. ....

Walid Abi Saab , Committee For Medicinal Products Human , European Union , European Medicines Agency , Medicinal Products , Human Use , Chief Medical Officer Walid Abi Saab , Product Characteristics , Risk Management , Rheumatoid Arthritis , Ulcerative Colitis , Jak Stat , Ak Stat Signaling Pathway , Ak Stat Cytokine Receptors , Male Factor Infertility , Disease Modifying Antirheumatic Drugs Dmards , Mard Disease Modifying Antirheumatic Drug , Ankylosing Spondylitis Bechterews Disease , Ankylosing Spondylitis , Crohns Disease ,

Abrocitinib Studied as Second-Line Biologic in Atopic Dermatitis

Abrocitinib shows consistent efficacy and safety in patients with moderate-to-severe atopic dermatitis, whether or not they ve already been treated with a biologic, researchers report. ....

Winston Salem , North Carolina , United States , Wake Forest University , Vanderbilt University , Lindsayc Strowd , Melinda Gooderham , Jamil Miller , Skin Centre For Dermatology , Vanderbilt University Medical Center , Drug Administration , Society For Investigative Dermatology , Investigative Dermatology , Bio Experienced With , Global Assessment , Eczema Area , Severity Index , Expand Treatment , Medscape Medical , Wake Forest University School , Atopic Dermatitis , Jak Stat , Ak Stat Signaling Pathway , Ak Stat Cytokine Receptors , Biologic Therapy ,