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Advances in the management of systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a severe multisystem autoimmune disease that can cause injury in almost every body system. While considered a classic example of autoimmunity, it is still relatively poorly understood. Treatment with immunosuppressive agents is challenging, as many agents are relatively non-specific, and the underlying disease is characterized by unpredictable flares and remissions. This State of The Art Review provides a comprehensive current summary of systemic lupus erythematosus based on recent literature. In basic and translational science, this summary includes the current state of genetics, epigenetics, differences by ancestry, and updates about the molecular and immunological pathogenesis of systemic lupus erythematosus. In clinical science, the summary includes updates in diagnosis and classification, clinical features and subphenotypes, and current guidelines and strategies for treatment. The paper also provides a comprehensive review of the large number ....

United States , British Isles , United Kingdom General , United Kingdom , Timothyb Niewold , Zenas Biopharma , Eli Lilly , Ruth Fernandez Ruiz , Ericf Morand , Research Council Of Australia , Lupus Research Foundation , Lupus Research Alliance , American College Of Rheumatology , Lupus Foundation Of America Project , European Alliance Of Associations , National Institutes Of Health , Thermo Fisher , Roivant Sciences , National Health , Art Review , African Americans , American College , European Alliance , Art Reviews , Medical Research Council , Lupus Research Alliance Diversity ,

Lupus Nephritis: Hopes, Questions Arise for Baricitinib

Results from a small, independently funded, double-blind, active-comparator trial suggest that baricitinib could be beneficial in the treatment of lupus nephritis. ....

United States , South Australia , Ericf Morand , Manal Hassanien , Eli Lilly , European Alliance Of Associations , Therapeutics Department At Assiut University , Monash Health Rheumatology Unit , Rheumatology Research , European Alliance , Advanced Therapeutics Department , Assiut University , Systemic Lupus Erythematosus , Lupus Nephritis , Jak Stat , Ak Stat Signaling Pathway , Ak Stat Cytokine Receptors , End Stage Renal Disease Esrd , End Stage Renal Disease , Rheumatoid Arthritis , Alopecia Areata ,

Lupus Nephritis Treatment Response Biomarkers Gain Ground

A panel of protein biomarkers in urine could achieve better identification of lupus nephritis patients who are likely to respond to treatment. ....

South Korea , South Australia , United States , Soult Ukpyolsi , Annexion Bio , Ericf Morand , School Of Clinical Sciences At Monash University , Shanghai Jiao Tong University , Johns Hopkins University , Andrea Fava , Huihua Ding , Clinical Sciences , Monash University , Systemic Lupus Erythematosus , Lupus Nephritis , Iological Marker ,

Baricitinib produces mixed results in pair of BRAVE lupus trials

Baricitinib met the primary endpoint in one phase 3 study of patients with systemic lupus erythematosus, but failed to meet the same endpoint in a second trial aiming to repeat the results, according to data published in The Lancet. ....

South Australia , Ericf Morand , Monash Health , Eli Lilly Co , Eli Lilly ,

Deucravacitinib and Orelabrutinib Perform Well in Lupus Trials

Disease activity was reduced by treatment with either of the novel investigational agents in two separate early clinical trials, with further trials planned. ....

South Australia , United States , Eli Lilly , Albert Roy , Ericf Morand , Bristol Myers Squibb , Zhanguo Li , School Of Clinical Sciences At Monash University , Lupus Research Alliance , Lupus Clinical Investigators Network , European Congress , Leeds England Institute Of Rheumatic , University People Hospital , Clinical Sciences , Monash University , Musculoskeletal Medicine , Leeds Teaching Hospitals , Distant Cousin , Lupus Therapeutics , Lupus Research , North American , Peking University People , Activity Index , Systemic Lupus Erythematosus , Clinical Research , Clinical Trials ,