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Zanubrutinib Plus Obinutuzumab and Venetoclax Induces High Undetectable MRD Rate in CLL/SLL

Zanubrutinib plus obinutuzumab and venetoclax demonstrated lasting responses characterized by sustained progression-free survival and undetectable minimal residual disease in peripheral blood and bone marrow in previously untreated patients with chronic lymphocytic leukemia or small lymphocytic lymphoma. ....

United States , Zanubrutinib Brukinsa , Jacob Soumerai , International Workshop , International Conference On Malignant Lymphoma , Hospital Cancer Center , Annual International Conference , Massachusetts General Hospital Cancer Center ,

Clinical Challenges: Using MRD in Chronic Lymphocytic Leukemia Management

Early indications that it could be used to guide the length of fixed-duration therapy ....

New York , United States , Memorial Sloan Kettering Cancer Center , Chapel Hill , Andrew Zelenetz , Jacob Soumerai , Daniel Persky , Catherine Coombs , American Society Of Hematology , Hospital Cancer Center , University Of North Carolina School Medicine , University Of Arizona College Medicine , North Carolina School , Arizona College , Massachusetts General Hospital Cancer Center , American Society , Chronic Lymphocytic Leukemia , Lymphocytic Leukemia , Peripheral Blood ,

Adaptive Biotechnologies Announces New Data Demonstrating the Benefit of Serial MRD Testing with the clonoSEQ® Assay in Patients with Blood Cancers at the 63rd ASH Annual Meeting

Adaptive Biotechnologies Announces New Data Demonstrating the Benefit of Serial MRD Testing with the clonoSEQ® Assay in Patients with Blood Cancers at the 63rd ASH Annual Meeting
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United States , Carrie Mendivil , Lance Baldo , Karina Calzadilla , Jacob Soumerai , Erica Schmitt , Exchange Commission , American Society Of Hematology , Adaptive Biotechnologies Corporation Nasdaq , Gilmartin Group , Hospital Cancer Center , Oneal Comprehensive Cancer Center , University Of Alabama At Birmingham , Biotechnologies Corporation , American Society , Annual Meeting , Autologous Transplantation , Adapted Consolidation , Final Primary Endpoint Analysis , Luciano Costa , Principal Investigator , O Neal Comprehensive Cancer Center , Chronic Lymphocytic Leukemia , High Risk Patient Cohort , Delayed Bone Marrow Undetectable , Earlier Post Treatment ,

MEI Pharma and Kyowa Kirin Announce New Clinical Data on Zandelisib at American Society of Clinical Oncology Annual Meeting 2021

MEI Pharma and Kyowa Kirin Announce New Clinical Data on Zandelisib at American Society of Clinical Oncology Annual Meeting 2021
-Zandelisib, an investigational agent, +/- rituximab demonstrated 82% overall response rate in patients with relapsed or refractory (r/r) follicular lymphoma (FL) who had progression of disease within 24 months of first line chemoimmunotherapy (POD24); overall response rate of 93% in non-POD24-
-An 8% discontinuation rate was observed in the combined study population-
-Zandelisib and zanubrutinib combination therapy demonstrated 100% response rate in patients with r/r indolent B-cell malignancies; combination administered on an optimized dosing regimen with no additive toxicity to each agent alone- ....

United States , Asia Pacific , Jacob Soumerai , Wojciech Jurczak , John Pagel , Department Of Clinical , Hospital Cancer Center , Swedish Cancer Center , Drug Administration , Beigene Ltd , Professor At Harvard Medical School , A Global Specialty Pharmaceutical Company , Sklodowska Curie National Research Institute , Kyowa Kirin Co Ltd , Pharma Inc , Rd Division Of Kyowa Kirin , Yoshifumi Torii , Executive Officer , Vice President , Clinical Data , Study Evaluating Zandelisib , Refractory Follicular , Inhibitor Zandelisib , Intermittent Schedule , Refractory Follicular Lymphoma , Hematologic Malignancies ,