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Organoids reveal similarities between myotonic dystrophy type 1 and Rett syndrome

Organoids reveal similarities between myotonic dystrophy type 1 and Rett syndrome
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How a single gene alteration may have separated modern humans from predecessors


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IMAGE: Neanderthal-ized brain organoids (left) look very different than modern human brain organoids (right) they have a distinctly different shape, and differ in the way their cells proliferate and how.
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Credit: UC San Diego Health Sciences
As a professor of pediatrics and cellular and molecular medicine at University of California San Diego School of Medicine, Alysson R. Muotri, PhD, has long studied how the brain develops and what goes wrong in neurological disorders. For almost as long, he has also been curious about the evolution of the human brain what changed that makes us so different from preceding Neanderthals and Denisovans, our closest evolutionary relatives, now extinct? ....

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