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#VisualAbstract: Iptacopan improves hematologic and clinical outcomes in paroxysmal nocturnal hemoglobinuria

1. In two clinical trials, iptacopan in patients with paroxysmal nocturnal hemoglobinuria (PNH) improved hemoglobin levels compared to anti-C5-treated patients and those without complement inhibitors. 2. Patients who received iptacopan generally exhibited improved secondary outcomes, including less fatigue, reduced reticulocyte and bilirubin levels, and decreased breakthrough hemolysis. Evidence Rating Level: 1 (Excellent) Study Rundown: PNH is a

Iptacopan improves hematologic and clinical outcomes in paroxysmal nocturnal hemoglobinuria

1. In two clinical trials, iptacopan in patients with paroxysmal nocturnal hemoglobinuria (PNH) improved hemoglobin levels compared to anti-C5-treated patients and those without complement inhibitors. 2. Patients who received iptacopan generally exhibited improved secondary outcomes, including less fatigue, reduced reticulocyte and bilirubin levels, and decreased breakthrough hemolysis. Evidence Rating Level: 1 (Excellent) Study Rundown: PNH

Novartis reports success in phase 3 trial of drug for rare kidney disease

Novartis reports positive topline results from a Phase 3 trial of iptacopan, a drug to treat a rare kidney disease, C3 glomerulopathy.

Phase 3 APPLY-PNH Extension Data Show Sustained Benefit of Iptacopan (Fabhalta) for PNH

Novartis: Phase III Study Shows Superiority Of Iptacopan In Patients With C3 Glomerulopathy

Novartis (NVS) reported positive topline results from the six-month, double-blind period of the Phase III APPEAR-C3G study of iptacopan for the treatment of patients with C3 glomerulopathy.

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