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Shedding new light on the hidden organization of the cytoplasm

Back in 2018, the lab of Christine Mayr, MD, PhD, at Memorial Sloan Kettering Cancer Center (MSK) introduced the world to a key cellular component that had been hiding in plain sight. ....

Christine Mayr , Ellen Horste , Sloan Kettering Institute , Memorial Sloan Kettering Cancer Center , Sloan Kettering Cancer , Molecular Cell , Gerstner Sloan Kettering Graduate School , Memorial Sloan Kettering Cancer , Cellular Biology ,

Intracellular journey: The penetration of antidepressants into cells, organelles, and membranes

Researchers in neuropsychopharmacology challenge conventional wisdom about antidepressants' actions, revealing significant intracellular activity that influences their effectiveness. Utilizing advanced technologies, the study prompts a reevaluation of drug targeting and mechanisms, opening new avenues for treating depression. ....

Christoph Burgstedt , Drug Administration , Subcellular Drug , Selective Serotonin Reuptake Inhibitors , N Methyld Aspartate Receptor ,

New technology can rapidly analyze the metabolic state of lipids in cells

Professor Itaru Hamachi, Lecturer Tomonori Tamura, and Assistant Professor Masaki Tsuchiya of Kyoto University have developed a new technology called O-ClickFC (Organelle-selective click labeling with flow cytometry), which can, at a very high speed, analyze the metabolic state of lipids in cells. ....

Emily Henderson , Masaki Tsuchiya , Tomonori Tamura , Kyoto University , Itaru Hamachi , Lecturer Tomonori Tamura , Assistant Professor Masaki Tsuchiya , Industry Focus , Flow Cytometry , Fluorescent Dyes , Genome Editing , Living Cells , Mass Spectrometry ,