Latest Breaking News On - International diabetes federation atlas - Page 1 : comparemela.com

Type 2 diabetes mellitus (T2D), a major cause of worldwide morbidity and mortality, is characterized by dysfunction of insulin-producing pancreatic islet β cells1,2. T2D genome-wide association studies (GWAS) have identified hundreds of signals in non-coding and β cell regulatory genomic regions, but deciphering their biological mechanisms remains challenging3–5. Here, to identify early disease-driving events, we performed traditional and multiplexed pancreatic tissue imaging, sorted-islet cell transcriptomics and islet functional analysis of early-stage T2D and control donors. By integrating diverse modalities, we show that early-stage T2D is characterized by β cell-intrinsic defects that can be proportioned into gene regulatory modules with enrichment in signals of genetic risk. After identifying the β cell hub gene and transcription factor RFX6 within one such module, we demonstrated multiple layers of genetic risk that converge on an RFX6

Robertc turnerArrojoe drigoFoundation for statistical computingHuman pancreas analysis programIslet distribution programInternational diabetes federation atlasRr core teamHaplotype reference consortiumHuman pancreas analysisCell metabIntegrated islet distribution programApplied longitudinal analysisGene ontologyAcids resCell proteomicsGenome biol