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RNA-targeted therapy shows promise for childhood dementia

Scientists have shown that a new RNA-targeted therapy can halt the progression of a specific type of childhood dementia in mice. ....

New South Wales , Russell Dale , Kris Elvidge , Barney Viengkhou , Childhood Dementia Initiative , Head Of Research , Ionis Pharmaceuticals , University Of Sydney , Clinical Investigation , Childhood Dementia , Professor Russell Dale , University Of Sydney , Icardi Goutières Syndrome , He Journal Of Clinical Investigation ,

Study reveals key protein's role in balancing immune response to viral infections

Researchers have revealed the regulatory mechanism of a specific protein that plays a key role in balancing the immune response triggered by viral infections in mammal cells. ....

Tomoko Takahashi , Maebashi Institute Of Technology , Saitama University , University Of Tokyo , Kyoto University , Chiba University , Kumiko Ui Tei , Maebashi Institute , Immune Response , Ell Death , Ucleic Acid , Programmed Cell Death ,

Aging affects immune response and virus dynamics in COVID-19 patients, study finds

A study examining 1031 hospitalized COVID-19 patients found that aging significantly impacts immune responses, viral dynamics, and the nasal microbiome, with older adults experiencing more severe disease symptoms and delayed viral clearance. ....

United States , Science Translational Medicine , Corona Borealis Studio , Severe Acute Respiratory Syndrome Coronavirus , Phenotyping Assessment , Covid 19 , Immune Response , Interleukin 6 , Ars Cov 2 ,

Rethinking the germ theory: A balanced take on microbes and disease outcomes

Review explores the complexities of infectious disease outcomes through a balanced perspective, emphasizing the interplay between pathogenic microbes and host conditions, challenging the traditional germ-disease theory by proposing a more integrated view that considers both pathogen virulence and host immunity's impact on disease manifestation. ....

Clostridium Difficile , Infectious Diseases ,

Interferon-beta deficiency alters brain response in neuroHIV mouse model

NeuroHIV refers to the effects of HIV infection on the brain or central nervous system and, to some extent, the spinal cord and peripheral nervous system. ....

United States , Marcus Kaul , Drug Administration , National Institutes Of Health , Scripps Research Institute In La Jolla , University Of California , School Of Medicine , National Institute Of Health , National Institutes , Scripps Research Institute , Macrophage Derived Cysteinyl Leukotrienes , National Institute , Cell Signaling , Central Nervous System , Hiv 1 , Ouse Model , Nervous System ,